Use of .alpha..sub.1A -selective adrenoceptor agonists for the t

Details Use of .alpha..sub.1A -selective adrenoceptor agonists for the t Use of .alpha..sub.1A -selective adrenoceptor agonists for the t

1995-06-02

1997-03-11

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514402, 514400, 514396, 514605, 514394, 514414, 514415, 514418, 514452, 514466, A61K 31415, A61K 3118, A61K 3140, A61K 31405

Patent

active

056101740

ABSTRACT:
The present invention provides a method of treating urinary incontinence in a subject which comprises administering to the subject a therapeutically effective amount of a compound having the following structure: ##STR1## wherein each of the substiutents for the compound is as defined in the specification.

REFERENCES:
patent: 4634705 (1987-01-01), DeBernardis et al.
Forray, Carlos et al., "The Alpha1-Adrenergic Receptor that Mediates Smooth Muscle Contraction in Human Prostate has the Pharmacological Properties of the Cloned Human Alpha1c Subtype," Molecular Pharmacology (1994), vol. 45, pp. 703-708.
Hatano, Akihiko et al., "Pharmacological evidence of distinct Alpha1-Adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery," British Journal of Pharmacology (1994), vol. 113, pp. 723-727.
Testa, Rodolfo et al., "Characterization of Alpha1-Adrenoceptor subtypes in prostate and prostatic urethra of rat, rabbit, dog and man," European Journal of Pharmacology (1993), vol. 249, pp. 307-315.
Watson, Steve and Girdlestone, Debbie, "1995 Receptor & Ion Channel Nomenclature Supplement--Trends in Pharmacological Sciences." Trends in Pharmacological Sciences (1995) Sixth Edition, pp. 1-13.
Kyncl et al, Chemical Abstracts, vol. 110, No. 17, Abstract No. 14763v, 1989.
Kontani et al, Chemical Abstracts, vol. 117, No. 1, Abstract No. 576b, 1992 .

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