Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-03-23
1999-07-13
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3800
Patent
active
059226790
ABSTRACT:
Neuronal nicotinic acetylcholine receptors (nAChRs) are believed to mediate nicotine addiction. In addition, stimulation of nAChRs modulates release of neurotransmitters including dopamine, norepinephrine and serotonin. Thus, pharmacological manipulation of nicotinic receptors has implications for a wide variety of disorders including psychotic, mood, movement and cognitive. For most nAChRs, there are no subtype selective ligands. However, .alpha.-conotoxin MII, a small peptide from the carnivorous marine snail Conus magus, was recently isolated. This peptide has been shown to be a specific antagonist for .alpha.3.beta.2 nicotinic receptors. The peptide potently blocks part, but not all, of nicotine-stimulated dopamine release from rat brain striatal synaptosomes. In contrast it has no effect on potassium stimulated dopamine release. Other .alpha.-conotoxins specifically target distinct neuronal nAChR subtypes. .alpha.-Conotoxins thus represent new lead compounds for CNS disorders.
REFERENCES:
Silverstone et al, J. Psycho pharmacol. 6(4) 462-482, 1992.
Medline AN 96392396, Laruelle et al, Aug. 20, 1996.
Rapier et al, J. Neurochem. 54 (3) 937-945, 1990.
Kulak Jennifer M.
McIntosh J. Michael
Olivera Baldomero M.
Yoshikami Doju
Cook Rebecca
University of Utah Research Foundation
LandOfFree
Use of .alpha.-conotoxin MII to treat disorders resulting from n does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of .alpha.-conotoxin MII to treat disorders resulting from n, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of .alpha.-conotoxin MII to treat disorders resulting from n will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2275709