Use of .alpha.-conotoxin MII to treat disorders resulting from n

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 3800

Patent

active

059290340

ABSTRACT:
Neuronal nicotinic acetylcholine receptors (nAChRs) are believed to mediate nicotine addiction. In addition, stimulation of nAChRs modulates release of neurotransmitters including dopamine, norepinephrine and serotonin. Thus, pharmacological manipulation of nicotinic receptors has implications for a wide variety of disorders including psychotic, mood, movement and cognitive. For most nAChRs, there are no subtype selective ligands. However, .alpha.-conotoxin MII, a small peptide from the carnivorous marine snail Conus magus, was recently isolated. This peptide has been shown to be a specific antagonist for .alpha.3.beta.2 nicotinic receptors. The peptide potently blocks part, but not all, of nicotine-stimulated dopamine release from rat brain striatal synaptosomes. In contrast it has no effect on potassium stimulated dopamine release. Other .alpha.-conotoxins specifically target distinct neuronal nAChR subtypes. .alpha.-Conotoxins thus represent new lead compounds for CNS disorders.

REFERENCES:
Rapier et al, J. Neurochem. 54(3) 937-945, 1990.
Barochovsky et al, J. Neurochem. 48(3)798-803, 1987.
Grady et al, J. Neurochem 59(3) 848-856, 1992.
Merch Manual, pp. 1592-1614, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of .alpha.-conotoxin MII to treat disorders resulting from n does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of .alpha.-conotoxin MII to treat disorders resulting from n, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of .alpha.-conotoxin MII to treat disorders resulting from n will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-878750

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.