Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-03-23
1999-07-27
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3800
Patent
active
059290340
ABSTRACT:
Neuronal nicotinic acetylcholine receptors (nAChRs) are believed to mediate nicotine addiction. In addition, stimulation of nAChRs modulates release of neurotransmitters including dopamine, norepinephrine and serotonin. Thus, pharmacological manipulation of nicotinic receptors has implications for a wide variety of disorders including psychotic, mood, movement and cognitive. For most nAChRs, there are no subtype selective ligands. However, .alpha.-conotoxin MII, a small peptide from the carnivorous marine snail Conus magus, was recently isolated. This peptide has been shown to be a specific antagonist for .alpha.3.beta.2 nicotinic receptors. The peptide potently blocks part, but not all, of nicotine-stimulated dopamine release from rat brain striatal synaptosomes. In contrast it has no effect on potassium stimulated dopamine release. Other .alpha.-conotoxins specifically target distinct neuronal nAChR subtypes. .alpha.-Conotoxins thus represent new lead compounds for CNS disorders.
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Rapier et al, J. Neurochem. 54(3) 937-945, 1990.
Barochovsky et al, J. Neurochem. 48(3)798-803, 1987.
Grady et al, J. Neurochem 59(3) 848-856, 1992.
Merch Manual, pp. 1592-1614, 1992.
Kulak Jennifer M.
McIntosh J. Michael
Olivera Baldomero M.
Yoshikami Doju
Cook Rebecca
University of Utah Research Foundation
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