Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1995-12-28
1997-09-16
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514173, A61K 3171
Patent
active
056681259
ABSTRACT:
This invention discloses a method of using an aldosterone antagonist such as spironolactone, at a dosage which does not disrupt a patient's normal electrolyte and water-retention balance, to inhibit myocardial fibrosis, including left ventricular hypertrophy (LVH).
REFERENCES:
patent: 4003996 (1977-01-01), Pappo
American Journal of Cardiology, Klug et al., "Role of Mechanical and Hormonal Factors in Cardiac Remodeling and the Biologic Limits of Myocardial Adaptation," Jan. 21, 1993, vol. 71, No. 3, pp. 46A-54A.
Journal of Molecular and Cellular Cardiology, Brilla et al., "Anti-Aldosterone Treatment and the Prevention of Myocardial Fibrosis in Primary and Secondary Hyperaldosteronism," May 1993, vol. 25, No. 5, pp. 563-575.
American Journal of Cardiology, Brilla et al., "Antifibrotic Effects of Spironolactone in Preventing Myocardial Fibrosis in Systemic Arterial Hypertension," Jan. 21, 1993, vol. 71, No. 3 pp. 12A-16A.
Journal of Pharmacology and Experimental Therapeutics, "Three New Epoxy-Spirolactone Derivatives; Characterization in vivo and in vitro," Feb. 1987, vol. 240, No. 2, pp. 650-666.
Budesverbrand D. Pharm. Ind. E.V., "Rote Liste," 1987 Editio Cantor, Aulendorft/Wortt.
Remington Pharmaceutical Sciences, 1975, pp. 867-868.
Doering, C.W., et al., "Collagen Network Remodeling and Diastolic Stiffness of the Rat Left Ventricle With Pressure Overload Hypertrophy," Cardiovasc. Res. 22: 686-695 (1988).
Brilla, C.G., et al., "Remodeling of the Rat Right and Left Ventricle in Experimental Hypertension," Circ. Res. 67: 1355-1364 (1990).
Weber, K.T., et al., "Structual Remodeling of Myocardial Collagen in Systemic Hypertension: Functional Consequences and Potential Therapy," Heart Failure 6: 129-137 (1990).
Weber, K.T., et al., "Myocardial Remodeling and Pathologic Hypertrophy," Hospital Practice 26(4): 73-80 (1991).
Andreoli, T.E., "Introduction: Modern Aspects of Congestive Heart Failure," Hospital Practice 26(4): 7-8 (1991).
Brilla, C.G., et al., abstract, "Myocardial Fibrosis in Experimental Hyertension: Potential Role of Fibroblast Corticoid Receptors," J. Hypertension 8: S8 (1990).
Weber, K.T., and Brilla, C.G., "Pathological Hypertrophy and Cardiac Interstitium: Fibrosis and Renin-Angiotension-Aldosterone System," Circulation 83: 1849-1865 (Jun. 1991).
Weber, K.T., and Brilla, C.G., "Myocardial Fibrosis and Elevations in Plasma Aldosterone in Arterial Hypertension," Aldosterone: Fundamental Aspects 215: 117-120 (1991).
Brilla, C.G. and Weber, K.T., "Prevention of Myocardial Fibrosis in Hypertension: Role of Fibroblast Corticoid Receptors and Spironolactone," Proceedings of the 75th Annual Meeting of the Fed. of Amer. Societies for Exper. Biology, 1991, abstract No. A1256, published Apr. 21, 1991.
Brilla et al, "Myocardial Fibrosism Experimental Hypertension: Potential Role of Fibroblast Corticoid Steroid Receptors," J. Hypertension, S8, 1990, Abstract.
Remington's Pharmaceutical Sciences, 15th Edition, 1975, pp. 867-868.
LandOfFree
Use of aldosterone antagonists to inhibit myocardial fibrosis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of aldosterone antagonists to inhibit myocardial fibrosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of aldosterone antagonists to inhibit myocardial fibrosis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-218334