Use of alanyl aminopeptidase inhibitors and pharmaceutical...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S247000

Reexamination Certificate

active

10520014

ABSTRACT:
The present invention relates to the use of one inhibitor or of several inhibitors of alanyl aminopeptidases and/or of enzymes having a similar substrate specificity for the induction of the production of TGF-β1 and of the expression of TGF-β1 in and/or on Treg cells and relates to the use for preventing and/or treating autoimmune diseases, allergies, arteriosclerosis and for suppressing graft rejection reactions. The invention furthermore relates to uses, wherein peptide fragments of pathogenic autoantigens or synthetic analogs and/or specific antigenic components of pathogenic microorganisms are used in addition.

REFERENCES:
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Kakuta et al. “Novel specific puromycin-sensitive aminopeptidase inhibitors: 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione and N-(2,6-diethylphenyl)-2-amino-4H-3,1-benzoxazin-4-one,” Heterocycles, 2001, 55, 1433, abstract only.
Sharabi et al. “A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta.” PNAS, 2006, 103, 8810-5.
Youn et al. “Metallothionein suppresses collagen-induced arthritis via induction of TGF-beta and down-regulation of proinflammatory mediators.” Clin. Exp. Immunol., 2002, 129, 232-9.
Le et al. “The immunopharmacological properties of transforming growth factor beta.” Int. Immunopharm., 2005, 5, 1771-82.
Ansorge, et al.; Dipeptidyl Peptidase IV/CD26 and Aminopeptidase N/CD13 in Regulation of the Immune Response; In: International Congress Series, 2001, 1218 (Cell-Surface Aminopeptidases: Basic and Clinical Aspects), pp. 85-94.

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