Use of AIM3 acting as a tumor suppressor

Details Use of AIM3 acting as a tumor suppressor Use of AIM3 acting as a tumor suppressor

2011-03-08

2011-03-08

Goddard, Laura B (Department: 1642)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

Reexamination Certificate

active

07902165

ABSTRACT:
The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.

REFERENCES:
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