Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2008-04-03
2011-12-27
Davis, Brian J (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C564S240000
Reexamination Certificate
active
08084502
ABSTRACT:
A use method of agmatine or a pharmaceutically allowable salt thereof, and a pharmaceutical composition comprising the same are disclosed. The method and pharmaceutical composition of the present invention can effectively cure or prevent eye diseases preferably including glaucoma, retinopathy, and optic neuropathy associated with apoptosis in retinal ganglion cells (RGCs), particularly hypoxia-induced or tumor necrosis factor-α (TNF-α)-induced apoptosis.
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patent: WO 99/08669 (1999-02-01), None
The Merck Index 14thed. version 14.6, O'Neil, Maryadele J. et al editors, 2006, 2010 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Whitehouse Station, NJ, entry No. 00188 Agmatine.
Hong, Samin et al. “Agmatin protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line.” BMC Neuroscience. Oct. 2, 2007, Vo1.8, No. 81, pp. 1-11.
Hong Samin
Kim Chan Yun
Lee Jong Eun
Seong Gong Je
Davis Brian J
Mannava & Kang, PC
Park Hyunho
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