Use of agents which bind G proteins for treating septic shock

Details Use of agents which bind G proteins for treating septic shock Use of agents which bind G proteins for treating septic shock

2005-09-27

2005-09-27

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S014800

Reexamination Certificate

active

06949507

ABSTRACT:
The present invention provides for the use of G protein binding agents for prophylactic and/or therapeutic treatments of septic shock. The present invention provides methods of using agents which bind G protein to treat a subject having or susceptible to septic shock. The present invention further pertains to compositions for treating a subject for septic shock. The composition includes an effective amount of a G protein binding agent and, optionally, an antibiotic and a pharmaceutically acceptable carrier. Other aspects of the invention include packaged agents which bind G proteins for treating septic shock.

REFERENCES:
patent: 5198420 (1993-03-01), Donahoe et al.
patent: 5492898 (1996-02-01), Bertics et al.
patent: 5556757 (1996-09-01), Alstyne et al.
patent: 5589459 (1996-12-01), Porro
patent: 5589568 (1996-12-01), Higashijima et al.
patent: 5627262 (1997-05-01), Pereira
patent: 5652211 (1997-07-01), Porro
patent: 5726155 (1998-03-01), Bokoch et al.
patent: 6583110 (2003-06-01), Finberg et al.
Higashijima et al. Conformational change of mastoparan from wasp venom on binding with phospholipid membrane. FEBS Letters. Feb. 1983, vol. 152, No. 2, pp. 227-230.
Cabeza-Arvelaiz, Y. et al. “Cholera and Pertussis Exotoxins Protect Mice . . . ”. Lymphokine Research. vol. 9, No. 2, pp. 125-135 (1990).
Proctor, R.a. et al. “Protection of Mice from Endotoxic Death by 2-methylthio-ATP”. Proc. Natl. Acad. Sci. USA. vol. 91, pp. 6017-6020 (Jun. 1994).
Hailman, E. et al. “Lipopolysaccharide (LPS)-binding Protein Accelerates the Binding of LPS to CD14”J. Exp. Med.179:269-277 (Jan. 1994).
Higashijima, T. et al. “Mastoparan, a Peptide Toxin from Wasp Venom, Mimics Receptors by Activating GTP-binding Regulatory Proteins (G Proteins)”The Journal of Biological Chemistry263(14):6491-6494 (May 15, 1988).
Higashijima, T. et al. “Regulation of Gland Goby Mastoparan, Regulated Amphiphilic Peptides, and Hydrophobic Amines”The Journal of Biological Chemistry265(24):14176-14186 ( 1990).
Higashijima, T. and Ross, E.M. “Mapping of the Mastoparan-binding Site on G Proteins”The Journal of Biological Chemistry266(19):12655-12661 (Jul. 5, 1991).
Kaziro, Y. et al. “Structure and Function on Signal-transducing GTP-binding Proteins”Annu. Rev. Biochem.60:349-400 (1991).
Neer, E.J. “Heterotrimeric G Proteins: Organizers of Transmembrane Signals”Cell80:249-257 (Jan. 27, 1995).
Saito, K. et al. “Synthesis of a Wasp Venom Tetradecapeptide, Mastoparan, with a New Cleaving System for 4-Methoxy-2,3,6-trimethylbenzene-sulfonyl (mtr) Amino-Protecting Group”Chem. Pharm. Bull.32(6):2187-2193 (1984).
Shenoy-Scaria, A.M. et al. “Palmitylation of an Amino-Terminal Cysteine Motif of Protein Tyrosine Kinases p56lckand p59fynMediates Interaction with Glycosyl-Phosphatidylinositol-Anchored Proteins”Molecular and Cellular Biology13(10):6385-6392 (Oct. 1993).
Schumann, R.R. et al. “Structure and Function of Lipopolysaccharide Binding Protein”Science249:1429-1431 (Sep. 21, 1990).
Solomon, K.R. et al. “The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein α subunits in lymphocytes”Proc. Natl. Acad. Sci. USA93:6053-6058 (Jun. 1996).
Solomon, K. et al. “G proteins regulate LPS mediated cytokine release”Clinical Infectious Diseases25(2):370, Abstr. 83 (1997).
{hacek over (S)}tefanová, I. et al. “GPI-Anchoredc Cell-Surface Molecules Complexed to Protein Tyrosine Kinases”Science254:1016-1018 (Nov. 15, 1991).
Sukumar, M. and Higashijima, T. “G Protein-bound Conformation of Mastoparan-X, a Receptor-Mimetic Peptide”The Journal of Biological Chemistry267(30):21421-21424 (Oct. 25, 1992).
Sweet, M.J. and Hume, D.A. “Endotoxin signal transduction in macrophages”Journal of Leukocyte Biology60:8-26 (1996).
Wurfel, M.M. et al. “Soluble CD14 Acts as a Shuttle in the Neutralization of Lipopolysaccharide (LPS) by LPS-binding Protein and Reconstituted High Density Lipoprotein”J. Exp. Med.181:1743-1754 (May 1995).
Wurfel, M.M and Wright, S.D. “Lipopolysaccharide-Binding Protein and Soluble CD14 Transfer Lipopolysaccharide to Phospholipid Bilayers”The Journal of Immunology158:3925-3934 (1997).
Yu, B. et al. “Lipopolysaccharide Binding Protein and Soluble CD14 Catalyze Exchange of Phospholipids”J. Clin. Invest.99(2):315-324 (Jan. 1997).

Affiliated with

Also associated with

Rating

Use of agents which bind G proteins for treating septic shock does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of agents which bind G proteins for treating septic shock, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of agents which bind G proteins for treating septic shock will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3447427