Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2005-01-11
2005-01-11
Lankford, Jr., Leon B. (Department: 1651)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C435S377000, C435S325000, C435S366000, C435S395000, C435S455000, C424S093210
Reexamination Certificate
active
06841150
ABSTRACT:
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.
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Gimble Jeffrey Martin
Halvorsen Yuan-Di C.
Wilkison William O.
Artecal, Sciences, Inc.
Lankford , Jr. Leon B.
Morgan, Lewis & Bockius, L.L.P.
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