Use of adenosine uptake inhibitors for treating retinal or optic

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514528, 514912, A61K 3170, A61K 31505

Patent

active

057804508

ABSTRACT:
Compositions and methods directed to the use of adenosine uptake inhibitors for the treatment of retinal and optic nerve head damage following acute or chronic glaucoma, edema, ischemia, hypoxia or trauma are disclosed.

REFERENCES:
patent: 4550022 (1985-10-01), Garabedian et al.
patent: 4912092 (1990-03-01), Gruber et al.
patent: 5075290 (1991-12-01), Findley et al.
patent: 5236908 (1993-08-01), Gruber et al.
patent: 5438060 (1995-08-01), Miyazaki et al.
Dreyer et al., A proposed role for excitatory amino acids in glaucoma visual loss, Investigative Ophthalmology and Visual Science, vol. 34 (suppl.), p. 1504 (1993).
Shimada et al., Differences in ischemia-induced accumulation of amino acids in the cat cortex, Stroke, vol. 21, No. 10, pp. 1445-1451 (1990).
Drejer et al., Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro, Journal of Neurochemistry. vol. 45, No. 1, pp. 145-151 (1985).
Benveniste et al. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, Journal of Neurochemistry, vol. 43, No. 5, pp. 1369-1374 (1984).
Beal, Mechanisms of exicitotoxicity in neurologic diseases, FASEB Journal, vol. 6, pp. 3338-3344 (1992).
Choi, Exicitotoxic cell death, Journal of Neurobiology, vol. 23, pp. 1261-1276 (1992).
Reif-Lehrer et al., Effects of monosodium glutamate on chick embryo retina in culture, Investigative Ophthalmology and Visual Science, vol. 14, No. 2, pp. 114-124 (1975).
Sisk et al., Histological changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate, Graefe's Archives of Clinical and Experimental Ophthalmology, vol. 223, pp. 250-258 (1985).
Sattayasai et al., Morphology of quisqualate-induced neurotoxicity in the chicken retina, Investigative Ophthalmology and Visual Science, vol. 28, pp. 106-117 (1987).
David et al., Involvement of exicitatory neurotransmitters in the damage produced in chick embryo retinas by anoxia and extracellular high potassium, Experimental Eye Research, vol. 46, pp. 657-662 (1988).
Tung et al., A quantitative analysis of the effects of excitatory neurotoxins on retinal ganglion cells in the chick, Visual Neuroscience, vol. 4, pp. 217-223 (1990).
Sucher et al., N-methyl-D-aspartate antagonists prevent kainate neurotoxocity in rat retinal ganglion cells in vitro, Journal of Neuroscience, vol. 11, pp. 966-971 (1991).
Siliprandi et al., N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina, VIsual Neuroscience, vol. 8, pp. 567-573 (1992).
Caprioli et al., Large retinal ganglion cells are more susceptible to excitotoxic and hypoxic injury than small cells, Investigative Ophthalmology and Visual Science, vol. 34 (suppl.), p. 1429 (1993).
Ramkumar, Adenosine, antioxidant enzymes and cytoprotection, Trends in Pharmacological Sciences, vol. 16, pp. 283-285 (1995).
Rudophi et al., Neuroprotective role of adenosine in cerebral ischemia, Trends in Pharmacological Sciences, vol. 13, pp. 439-445 (1992).
Deckert et al., Adenosine--an endogenous neuroprotective metabolite and neuromodulator, Journal of Neural Transmission, vol. 43 (suppl.), pp. 23-31 (1994).
Blazynski et al., Discrete Distributions of Adenosine Receptors in Mammalian Retina, Journal of Neurochemistry, vol. 54, No. 2, pp. 648-655 (1990).
Woods et al., Characterization of Adenosine a.sub.1 -Receptor Binding Sites in Bovine Retinal Membranes, Experimental Eye Research, vol. 53, pp. 325-331 (1991).
Braas et al., Endogenous adenosine and adenosine receptors localized to ganglion cells of the retina, Proceedings of the National Academy of Science, vol. 84, pp. 3906-3910 (1987).
Williams et al., Nucleoside Transport Sites in a Cultured Human Retinal Cell Line Established By Sv-40 T Antigen Gene, Current Eye Research, vol. 13, pp. 109-118 (1994).
Ophthalmic Surgery: Principles of Practice, Ed., G.L. Spaeth, W.B. Sanders Co. Philadelphia, PA, U.S.A., pp. 85-87 (1990).
Clanachan et al., Drug interactions with nucleoside transport systems, In: Gerlach E and Becker BF, eds. Topics and Perspectives in Adenosine Research, Springer-Verlag: Berlin, pp. 118-130 (1987).
Centelles et al., A model for adenosine transport and metabolism, Biochemical Journal, vol. 287, pp. 461-472 (1992). H!adenosine influx, Biochemical Pharmacology, vol. 46, No. 5, pp. 891-896 (1993).
Vijayalakshmi et al., L1210/B23.1 cells express equilibrative, inhibitor-sensitive nucleoside transport and lack two parental nucleoside transport activities, Journal of Biological Chemistry, vol. 267, No. 24, pp. 16951-16956 (1992).
Deckert et al., (H-3)Dipyridamole and (H-3)Nitrobenzylthioinosine binding sites at the human parietal cortex and erythrocyte adenosine transporter: a comparison, Life Sciences, vol. 55, No. 21, pp. 1675-1682 (1994).
Betcher et al., Sodium-adenosine cotransport in brush-border membranes from rabbit ileum, American Journal of Physiology, vol. 259, pp. G504-510 (1990).
Yeung et al., Erythrocyte adenosine transport. A rapid screening test for cardiovascular drugs, Journal of Pharmacological and Toxicological Methods, vol. 30, No. 3, pp. 163-167 (1993). probe for adenosine transport systems in rat brain synaptoneurosomes, Journal of Neurochemistry, vol. 56, No. 2, pp. 548-552 (1991).
Braunagel et al., The potential role of adnosine in regulating blood flow in the eye, J. Ocul. Pharmacol., vol. 4, No. 1, pp. 61-73 (1988).
Fern et al., Modulation of anoxic injury in CNS white matter by adenosine and interaction between adenosine and GABA, J. Neurophysiol., vol. 72, No. 6, pp. 2609-2616 (1994).
Resul et al., Structure-activity relationships of prostaglandin analogues as ocular hypotensive agents, Curr. Opin. Ther. Pat., vol. 3, No. 6, pp. 781-795 (1993).
Riva et al., Possible role of adenosine in the response of optic nerve head blood flow to neuronal stimulation, Exp. Eye Res., vol. 55, No. suppl.1, sec, 278 (1992).
Vargas et al, Trombosis de la vena central de la retina, Angiologia, vol. 26, No. 3, pp. 112-116 (1974).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of adenosine uptake inhibitors for treating retinal or optic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of adenosine uptake inhibitors for treating retinal or optic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of adenosine uptake inhibitors for treating retinal or optic will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1881843

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.