Use of adenosine, hypoxanthine and ribose-containing solution fo

Details Use of adenosine, hypoxanthine and ribose-containing solution fo Use of adenosine, hypoxanthine and ribose-containing solution fo

1988-09-29

1989-11-14

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 514921, 536 24, 536 26, A61K 3170

Patent

active

048807834

ABSTRACT:
The invention relates to an improved cardioplegic solution for reducing ischemic damage to the heart during operations and/or transplantation. The invented solution contains adenosine, hypoxanthine and ribose in addition to the electrolytes contained in standard cardioplegic solutions.

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Schrader et al, "Inhibitation of Slow Action Potentials of Guinea Pig A Trial Muscle by Adenosine: A Possible Effect on Ca.sup.2+ Influx,", Journal of Molecular and Cellular Cardiology (1975) 7, 427-433.
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