Use of adenosine compounds for autonomic nervous system attenuat

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 47, 536 2623, 536 2626, 536 267, 536 276, A61K 3170

Patent

active

056796498

ABSTRACT:
A method of inducing anesthesia, sedation, analgesia, hypothermia, and reduced stress by administering an effective amount of an adenosine compound to a mammal. It also provides a method for preserving donor organs in vivo by contacting them with an adenosine compound, as well as a method for preparing organ recipients for transplant.

REFERENCES:
patent: 4605644 (1986-08-01), Foker
patent: 4673563 (1987-06-01), Berne et al.
patent: 4755594 (1988-07-01), Bridges et al.
patent: 4880783 (1989-11-01), Mentzer, Jr. et al.
patent: 4880918 (1989-11-01), Rapaport
patent: 5049372 (1991-09-01), Rapaport
patent: 5104859 (1992-04-01), Sollevi
Fukunaga et al.(I), "ATP Induced Hypotensive Anesthesia During Surgery," Anesthesiology, 57, A65 (1982).
Fukunaga et al.(II), "Hypotensive Effects of Adenosine and Adenosine Triphosphate Compared with Sodium Nitroprusside," Anesthesiology, 61(3), 273-278 (1982).
Dunwiddie et al., "Sedative and Anticonvulsive Effects of Adenosine Analogs in Mouse and Rat," J. Pharm. and Expert Therapeutics, 220, 70-76 (1982).
Seitz et al., "Adenosine Reduces Halothane MAC in Dogs," Anesthesiology, 68, A263 (1989).
Homeister et al., "Combined Adenosine and Lidocaine Administration Limits Myocardial Reperfusion Injury," Circulation, 82(2), 595-608 (1990).
Gomma, "Characteristics of Analgesia Induced by Adenosine Triphosphate," Pharmacology and Toxicology, 61, 199-202 (1987).
Drury et al., "The Physiological Activity of Adenine Compounds with Especial Reference to Their Action Upon the Mammalian Heart," J. Physiology(Cambridge, England), 68, 213-237 (1929).
Vapaatalo et al., "Stereospecificity in Some Central and Circulatory Effects of Phenylisopropyladenosine (PIA)," Arzneim. Forsch. (Drug Res.), 25(3), 407-410(1975).
Phillis et al.(I), "Roles of Adenosine and Adenine Nucleotides in the Central Nervous System," in Physiology and Pharmacology of Adenosine Derivatives, Daly et al. eds., Raven Press, New York, 1983, pp. 219-235.
Phillis et al.(II), "Evidence for an A.sub.2 -like Receptor on Cerebral Cortical Neurons," J. Pharm. Pharmacol., 34, 453-454 (1982).
Nunn et al., "Introduction," in General Anesthesia, 5th Ed., Nunn et al. eds., Butterworth, London, 1989, pp. 1-6.
Ohisalo et al., "Regulatory Functions of Adenosine," Medical Biology, 65, 181-191 (1987).
Williams, "Tissue and Species Differences in Adenosine Receptors and Their Possible Relevance to Drug Development," in Adenosine: Receptors and Modulation of Cell Function, Stefanovich et al. (eds.), IRL Press Ltd., Oxford, UK, 1985, pp. 73-84.
Stoelting et al. (eds.), Principles of Anesthesia, 2nd Ed., Churchill Livingstone, New York, NY, 1989, pp. 115-119.
Katzung (ed.), Basic & Clinical Pharmacology, Ch. 24, Appleton & Lange, Norwalk, Connecticut, 1995, pp. 381-394.
Seitz et al., "Adenosine Decreases the Minimum Aveolar Concentration of Halothane in Dogs," Anesthesiology, 73, 990-994 (1990).
Orwall et al., "Clinical Experience with Adenosine for Controlled Hypotension During Cerebral Aneurysm Surgery," Anesthesiology and Analgesia, 66, 229-234 (1987).
Williams, "Purine Receptors in Mammalian Tissues: Pharmacology and Functional Significance," Ann. Rev. Pharmacology & Toxicology, 27, 315-345 (1987); see particularly pp. 316, 328-329 and 335 refer to hypnotic effects.
Haulica et al., "Preliinary Data on the Possibel Hypnogenic Role of Adenosine," J. Neurochem., 21, 10-19-1020 (1973).
Birch et al., "L-phenylisopropyladenosine (L-PIA) Diminishes Halothane Anesthetioc Requirements and Decreases Neurotransmission in Rats," Life Science, 42(14), 1355-1360 (1988); p. 1355, second paragraph, lines 5-7.
Conradson et al., "Cardiovascular Effects of Infused Adenosine: Potentiation by Dipyridamole," 129, 387-391 (1987). of Anesthetic Potency," Anesthesiology, 26, 756-763 (1965).
Snyder, "Adenosine as Neuromodulator," Ann. Rev. Neuroscience, 8, 103-124 (1985); see pp. 108 & 119, second paragraphs.
Bloor et al., "Reduction of Halothane Anesthetic Requirement by Clonidine, an Alpha-Adrenergic Agonist," Anesthesia and Analgesia, 61, 741-745 (1982).
Maze et al., "Anesthetic and Hemodynamic Effects of the Alpha.sub.2 -Adrenergic Agoinst, Azepexole, in Isoflurane-Anesthetized Dogs," Anesthesiology, 68(5), 689-694 (1988).
Segal et al., "Dexmedetomidine Diminishes Halothane Anesthetic Requirements in Rats Through a Post Synaptic Alpha.sub.2 Adrenergic Receptor," Anesthesiology, 68(6), 818-823 (1988); see particularly col. 2 of p. 818, last paragraph.
Tanifuji et al., "Effect of Arterial Hypotension on Anesthetic Requirements in Dogs," British J. Anesthesiology, 48(10), 947-951 (1976).
Dunwiddie, "The Physiological Role of Adenosine in the Central Nervous System," International Reviews in Neurobiology, 27, 63-139 (1985); see particularly pp. 95-99, 121 and 126-128.
Feldberg et al., "Injection of Drugs into the Left Ventricle of the Cat," J. Physiology London, 123, 148-167 (1954).
Radulovacki et al., "Hypnotic Effects of Deoxycoformycin in Rats," Brain Research, 27, 271, 392-395 (1983).
Jonzon et al., "Modulation of Neurotransmission by Purine Nucleosides and Nucleotides," Life Science, 1984, 1971-1979.
Galloway et al., "Clonidine Prevents Methylxanthine Stimulation of NE Metabolism in Rats," J. Neurochemistry, 40, 246-251 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of adenosine compounds for autonomic nervous system attenuat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of adenosine compounds for autonomic nervous system attenuat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of adenosine compounds for autonomic nervous system attenuat will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1006771

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.