Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-10-15
2010-11-30
Haddad, Maher M (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07842464
ABSTRACT:
The present invention relates to the significant role of ADAM 12, ADAM 12-L, and ADAM 12-S in preeclampsia and related disorders. The invention further relates to the use of said genes and gene products, ligands binding to those, and modulators of activity of the gene products in diagnosis and treatment of preeclampsia and related syndromes. The invention also relates to the use of further genes and combinations thereof in diagnosis of preeclampsia and related syndromes.
REFERENCES:
patent: 5744305 (1998-04-01), Fodor et al.
patent: 2003/0170627 (2003-09-01), Walker et al.
patent: 2004/0002467 (2004-01-01), Ward et al.
patent: 2006/0134654 (2006-06-01), Wewer et al.
patent: 2008/0292619 (2008-11-01), Sehara et al.
patent: WO 99/46597 (1999-09-01), None
patent: WO 03/020220 (2003-03-01), None
Laigaard et al. ADAM12: a novel first-trimester maternal serum marker for Down syndrome. Prenat Diagn. Dec. 30, 2003;23(13):1086-91.
Christiansen et al (2007): ADAM12 as a second-trimester maternal serum marker in screening for Down syndrome. Prenat Diagn 27, 611-615.
Wewer et al. ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme. J Biol Chem. 281(14)9418-9422, 2006.
Attwood TK. Genomics. The Babel of bioinformatics. Science. 290(5491):471-473, 2000.
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends Biotechnol. 18(1):34-9, 2000.
Barton et al. Semin. Gastrointestinal complications of pre-eclampsia. Perinatol. Jun. 2009;33(3):179-88.
Beaulieu, Canadian Guide to Clinical Preventive Health Care, Ottawa: Health Canada, 1994, 136-43.
Maniatis et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Lab, Cold Spring Harbor, NY, 1989, 16 pgs.
Altschul et al., Nucleic Acids Res., 25:3389-3402.
Feinberg, A.P. and Vogelstein, B. (1983), Anal. Biochem. 132:6-13.
Seals, D.F., and Courtneidge, S.A., the ADAMs Family of Metalloproteases: Multidomain Proteins with Multiple Functions, Genes & Dev. 17, 7-30, 2003.
Ng, E.K.O., Tsui, N.B.Y., et al., Proc. Natl. Acad. Sci. USA, 2003, vol. 100(8): 4748-53.
Shi et al., L.J. (2000), J. Biol. Chem. 275, 18574-18580.
Gilpin, B.J. et al., Journal of Biological Chemistry, vol. 273, No. 1 (1998) pp. 157-166.
Mizutani, S., Akiyama, H. Kurauchi, O., et al., (1985), Arch. Gynecol. 236(3): 165-72.
Tempfer, C.B., Bancher-Todesca, D., Zeisler, H., et al., 2000, Placental Expression and Serum Concentrations of Cytokeratin 19 in Preeclampsia, Obstet. Gynecol. 95(5): 677-82.
Miyawaki, A., Tsien, Methods Enzymol. 2000, vol. 327, pp. 472-500.
Tuschl, Nature Biotechnology, vol. 20, pp. 446-448.
Kolben M., et al., European Journal of Obstetrics, (1996), vol. 68, No. 1-2, pp. 59-65.
Masanori Asakura et al.: Nature Medicine, vol. 8, No. 1 (2002), pp. 35-40.
Pang Z. J. et al., British Journal of Biomedical Science, vol. 60, No. 2 (2003), pp. 97-101.
Database WPI, Derwent Publications Ltd., (1986). SU19853857363 Reznikov et al. Prognosis of pathological pregnancy—by measurign blood alpha-macroglobulin content for early predication of spontaneous abortion or pregnancy toxicosis. p. 1.
Leach R. E. et al., Lancet, vol. 360, No. 9341 (2002), pp. 1215-1219.
Schroeder, Barrett M., America Family Physician Practice Guidelines—AGOG Practice Bulletin on Diagnosing and Managing Preeclampisa and Eclampsia, Jul. 15, 2002; available at http://www.aafp.org/afp/2002715/practice.html.
Hofmeyr, et al. BMC Medicine, 2009 (7)11; available at http://www.biomedcentral.com/1741-7015/7/11.
Merck Manual, Abnormalities of Pregnancy: Preeclampsia and Eclampsia (last full review/revision Nov. 2005; content last modified Nov. 2005); available at http://www.merck.com/mmpe/sec18/ch263/ch263j.html.
Angel Peter
Gack Sabine
Lichter Peter
Marme Alexander
Schorpp-Kistner Marina
DKFZ Deutsches Krebsforschungszentrum
Foley & Lardner LLP
Haddad Maher M
LandOfFree
Use of ADAM 12 for diagnosis and therapy of preeclampsia does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of ADAM 12 for diagnosis and therapy of preeclampsia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of ADAM 12 for diagnosis and therapy of preeclampsia will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4240943