Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1986-08-14
1990-11-13
Epplinger, Esther M.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
435283, 4352401, 422 1, 422 17, A01N 102, C23F 1118
Patent
active
049701436
ABSTRACT:
Living tissue lacking sufficient oxygenation due to conditions including anoxia and ischemia is treated with an aqueous solution containing acetoacetate in an amount sufficient for affording protection of the tissue from the effects of insufficient oxygenation. The solution may be in a form of an isotonic, hypertonic, perfusion, or cardioplegic solution and also may contain pyruvate and glycerol.
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Dobrescu et al., "Relationship Between Glucose, Fatty Acid and Ketone Body Metabolism in Isolated Perfused Frog Heart," Rev. Roun. Bio.-Zoologie, vol. 18, No. 4, 1973, pp. 281-288.
Mayes et al., "Effect of Haematocki & Value and pO.sub.2 on the Redox State and Metabolism it Perfused Liver", Biochem. J., vol. 156, 1976, pp. 685-689.
Menahan et al., "Regulation of Acetoacetyl-CoA in Isolated Perfused Rat Hearts", Eue. J. Biochem., vol. 119, 1981, pp. 295-299.
Gomez Olga
Guidoux Rene
Epplinger Esther M.
Nestec S.A.
Spiegel Carol A.
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