Use of acetoacetate for preservation of living tissue

Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor

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435283, 4352401, 422 1, 422 17, A01N 102, C23F 1118

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active

049701436

ABSTRACT:
Living tissue lacking sufficient oxygenation due to conditions including anoxia and ischemia is treated with an aqueous solution containing acetoacetate in an amount sufficient for affording protection of the tissue from the effects of insufficient oxygenation. The solution may be in a form of an isotonic, hypertonic, perfusion, or cardioplegic solution and also may contain pyruvate and glycerol.

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Nishiitsutsuji-Uwo et al., "Metabolic Activities of the Isolated Perfused Rat Kidney", Biochem. J., 103, 1967, pp. 852-862.
Wieland et al., "Interconversion of Pyruvate Dehydrogenase in Rats Heart Muscle upon Perfusion with Fatty Acids or Ketone Bodies", FEBS Letters, 1971, vol. 15, No. 4, pp. 295-298.
Dobrescu et al., "Relationship Between Glucose, Fatty Acid and Ketone Body Metabolism in Isolated Perfused Frog Heart," Rev. Roun. Bio.-Zoologie, vol. 18, No. 4, 1973, pp. 281-288.
Mayes et al., "Effect of Haematocki & Value and pO.sub.2 on the Redox State and Metabolism it Perfused Liver", Biochem. J., vol. 156, 1976, pp. 685-689.
Menahan et al., "Regulation of Acetoacetyl-CoA in Isolated Perfused Rat Hearts", Eue. J. Biochem., vol. 119, 1981, pp. 295-299.

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