Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-02-29
2010-10-19
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07816400
ABSTRACT:
This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKuror IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).
REFERENCES:
patent: 2004/0087516 (2004-05-01), Rosenbloom
Lekakis, J. et al., European Journal of Cardiovascular Prevention & Rehabilitation, Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease, vol. 12, issue 6, pp. 596-600 (Dec. 2005).
Wallace, C.H.R. et al., British Journal of Pharmacology, Inhibition of cardiac voltage-gated sodium channels by grape polyphenols, vol. 149, pp. 657-665 (2006).
Brundel et al., Journal of the American College of Cardiology, Alterations in Potassium Channel Gene Expression in Atria of Patients with Persistent and Paroxysmal Atrial Fibrillation: Differential Regulation of Protein and mRNA Levels for K+ Channels, vol. 37, issue 3, pp. 926-932 (2001).
Calderone, V. et al., Naunyn-Schmiedeberg's Arch Pharmacol, Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels, vol. 370, pp. 290-298 (2004).
Merriam Webster Online Dictionary “derivative”; also available at http://www.merriam-webster.com/dictionary/derivative.
Merriam Webster Online Dictionary “analogue”; also available at http://www.merriam-webster.com/dictionary/analogue.
Merriam Webster Online Dictionary “glycoside”; also available at http://www.merriam-webster.com/dictionary/glycoside.
MayoClinic.com “cardiac arrhythmia”; also available at http://www.mayoclinic.com/health/heart-arrhythmias; last viewed Feb. 2, 2010.
Calderone, V. et al., Naunyn-Schmiedeberg's Arch Pharmacol: “Vasorelaxing effects of flavonoids: invetigation on the possible involvement of potassium channels”, vol. 370, pp. 290-298 (2004).
Benjamin, Emelia J. et al., “Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study,”Circulation: Journal of the American Heart Association, 1998, vol. 98, pp. 946-952.
Blaauw, Y. et al., “Early' Class III Drugs for the Treatment of Atrial Fibrillation: Efficacy and Atrial Selectivity of AVE0118 in Remodeled Atria of the Goat,”Circulation: Journal of the American Heart Association, 2004, vol. 110, pp. 1717-1724.
Bosch, Ralph F. et al., “Ionic mechanisms of electrical remodeling in human atrial fibrillation,”Cardiovascular Research, 1999, vol. 44, pp. 121-131.
Burashnikov, Alexander et al., “Atrium-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation: Differences in Sodium Channel Inactivation Between Atria and Ventricles and the Role of Ranolazine,”Circulation: Journal of the American Heart Association, 2007, vol. 116, pp. 1449-1457.
Cahill, Sean A. et al., “Propafenone and Its Metabolites Preferentially Inhibit IKrin Rabbit Ventricular Myocytes,”The Journal of Pharmacology and Experimental Therapeutics, 2004, vol. 308, No. 1, pp. 59-65.
Chiou, Chuen-Wang et al., “Efferent Vagal Innervation of the Canine Atria and Sinus and Atrioventricular Nodes,”Circulation: Journal of the American Heart Association, 1997, vol. 95, p. 2573-2584.
Courtemanche, Marc et al., “Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model,”Cardiovascular Research, 1999, vol. 42, pp. 477-489.
D'Aloia, Antonio D. et al., “Sustained torsade de pointes occurring early during oral sotalol therapy for atrial fibrillation recurrence prophylaxis in a patient without heart disease,”International Journal of Cardiology, 2005, vol. 105, pp. 337-339.
De Haan, Sunniva et al., “AVE0118, Blocker of the Transient Outward Current (Ito) and Ultrarapid Delayed Rectifier Current (IKur), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat,”Circulation: Journal of the American Heart Association, 2006, vol. 114, pp. 1234-1242.
Dong, Ming-Qing et al., “Characterization of Recombinant Human CardiacKCNQ1/KCNE1Channels (IKs) Stably Expressed in HEK 293 Cells,”Journal of Membrane Biology, 2006, vol. 210, pp. 183-192.
Doostdar, Hamed et al., “Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1,”Toxicology, 2000, vol. 144, pp. 31-38.
Fedida, David et al., “Identity of a Novel Delayed Rectifier Current From Human Heart With a Cloned K+Channel Current,”Circulation Research, Jul. 1993, vol. 73, No. 1, pp. 210-215.
Gao, Zhan et al., “Inhibition of ultra-rapid delayed rectifier K+current by verapamil in human atrial myocytes,”Journal of Molecular and Cellular Cardiology, 2004, vol. 36, pp. 257-263.
Gögelein, Heinz et al., “Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels,”Naunyn-Schmiedeberg's Arch. Pharmacol., 2004, vol. 370, pp. 183-192.
Hashimoto, Norio et al., “Tertiapin, a selective IKAChblocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation,”Pharmacological Research, 2006, vol. 54, pp. 136-141.
Hsu, Ya-Ling et al., “Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis,”Biochemical Pharmacology, 2004, vol. 67, pp. 823-829.
Kawaii, Satoru et al., “Quantitative Study of Flavonoids in Leaves ofCitrusPlants,”Journal of Agricultural Food Chemistry, 2000, vol. 48, pp. 3865-3871.
Kim, Young M. et al, “A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation,”Ciruclation Research: The Journal of the American Heart Association, 2005, vol. 97, pp. 629-636.
Kraft, Carola et al., “In Vitro Antiplasmodial Evaluation of Medicinal Plants from Zimbabwe,”Phytotherapy Research, 2003, vol. 17, pp. 123-128.
Li, Gui-Rong et al., “Adrenergic Modulation of Ultrarapid Delayed Rectifier K+Current in Human Atrial Myocytes,”Circulation Research, 1996, vol. 78, pp. 903-915.
Li, Gui-Rong et al., “Biphasic effects of cell vol. on excitation-contraction coupling in rabbit ventricular myocytes,”American Journal of Physiological Heart Circulation Physiology, 2002, vol. 282, pp. H1270-H1277.
Li, Gui-Rong et al., “Evidence for Two Components of Delayed Rectifier K+Current in Human Ventricular Myocytes,”Circulation Research, 1996, vol. 78, pp. 689-696.
Li, Gui-Rong et al., “Heterogeneity of Sodium Current in Atrial vs Epicardial Ventricular Myocytes of Adult Guinea Pig Hearts,”Journal of Molecular Cell Cardiology, 2002, vol. 34, pp. 1185-1194.
Liao, Yong-Hong et al., “Novel and Known Constituents fromBuddlejaSpecies and Their Activity against Leukocyte Eicosanoid Generation,”Journal of Natural Products, 1999, vol. 62, pp. 1241-1245.
Lip, Gregory Y.H. et al., “Management of atrial fibrillation,”Lancet, 2007, vol. 370, pp. 604-618.
Lloyd-Jones, Donald M. et al., “Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study,”Circulation: The Journal of the American Heart Association, 2004, vol. 110, pp. 1042-1046.
Mihm, Michael J. et al., “Impaired Myofibrillar Energetics and Oxidative Injury During Human Atrial Fibrillation,”Circulation: The Journal of the American Heart Association, 2001, vol. 104, pp. 174-180.
Milberg, Peter et al., “Comparison of the In Vitro Electrophysiologic and Proarrhythmic Effects of Amiodarone and Sotalol in a Rabbit Model of Acute Atrioventricular Block,”Journal of Cardiovascular Pharmacology, 2004, vol. 44, pp. 278-286.
Nattel, Stanley et al., “New Approaches to Atrial Fibrillation Management: A Critical Review of a Rapidly Evolving Field,&#x
Lau Chu-Pak
Li Gui-Rong
Qin Guo-Wei
Wang Hong-Bing
Jiang Shaojia Anna
Saliwanchik Lloyd & Saliwanchik
Schmidtmann Bahar
Shanghai Institute of Materia Medica Chinese Academy of Science
The University of Hong Kong
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