Use of a vitamin combination for the treatment of primary...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S318000, C546S319000, C546S320000, C544S251000, C514S251000

Reexamination Certificate

active

07456291

ABSTRACT:
Use of a combination of two vitamin compounds, i.e. riboflavin (also known as vitamin B2) and nicotinic acid (also referred to as niacin) or, as an alternative thereto, the corresponding amide, i.e. niacinamide or nicotinamide (also known as vitamin PP) for the treatment of various forms of primary headache, such as classical migraine or migraine with an aura, common migraine or migraine without an aura, complicated migraine and cluster headache or histamine headache. The invention also concerns compositions for the treatment of primary headaches which are based on the two aforesaid active ingredients.

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Schoenen et al., Cephalalgia, 1994;14(5):328-329.
Smith, Clifford. The Role of Riboflavin in Migraine.1946.Canada M.A.J. p. 589-591 ).
Fritton, Margarette. Uber die Behandlung der Migrane mit Nikotinsaureamide (Therapy of Migraine with Nicotinic Acid Amide).Sep. 17, 1955 (38).p. 1350-1.
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J. Schoenen et al., “High-Dose Riboflavin as a Prophylactic Treatment of Migraine: results of an open pilot study”, Cephalalgia, Scandinavian Press, NO, vol. 14, No. 5, 1994, pp. 328-329.

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