Use of a tocopherol phosphate or one of its derivatives for the

Details Use of a tocopherol phosphate or one of its derivatives for the Use of a tocopherol phosphate or one of its derivatives for the

1995-06-05

1997-07-01

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 73, 4241951, 424401, 514100, 514147, 514458, 514944, A61K 9127, A61K 31355

Patent

active

056435975

ABSTRACT:
Use of a tocopherol phosphate, other than alpha-tocopherol phosphate, especially in its dl or d form, or one of its esters having general formula (I) in which: R' is hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, R'O is a tocopheryl radical; R" is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, or R"O is an oxyethylene chain, of formula (a) in which R.sub.4 and R.sub.5 are independently a hydrogen atom or a methyl radical, and n is an integer of 1 or over; R.sub.1, R.sub.2 and R.sub.3 are independently a hydrogen atom or a methyl radical, it being understood that R.sub.1, R.sub.2 and R.sub.3 cannot simultaneously be a methyl radical. A represents the groups (b), or (c). The invention also concerns the use of cosmetically or of pharmaceutically acceptable salts of said compound in the preparation of cosmetic or pharmaceutical, especially dermatological, composition characterized by having a reduced allergizing or irritating potential, or used in the prevention or treatment of allergic conditions, such as cutaneous allergy or bronchial or inflammatory asthma, or in the prevention or treatment of the harmful effects of free radicals.

REFERENCES:
patent: 4914197 (1990-04-01), Yamamoto
patent: 5114957 (1992-05-01), Hendler
patent: 5387579 (1995-02-01), Meybeck
Kubo Chem. Pharm. Bull 33, No. 6, p. 2411, 1985.
Halliwell, Free Radicals in Biology and Medicine, Clarendon Press, p. 123, 1991.

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