Use of a thromboxane receptor antagonist in renal diseases and d

Details Use of a thromboxane receptor antagonist in renal diseases and d Use of a thromboxane receptor antagonist in renal diseases and d

1989-06-20

1990-11-06

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, 514315, 514869, C08B 3716, A61K 31715, A61K 31445

Patent

active

049686739

ABSTRACT:
The use is described of [1R-[1.alpha.(Z),2.beta.,3.beta.,5.alpha.]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid or a physiologically acceptable salt, solvate or cyclodextrin complex thereof in the manufacture of medicaments for the therapy or prophylaxis of chronic glomerular diseases including glomerulonephritis, lupus nephritis and systemic lupus erythematosus, renal failure, renal hypertension, hepatorenal syndrome, proteinurea (e.g. albuminurea and microalbuminurea), haemolytic uraemic syndrome and renal impairment following ureteral obstruction.

REFERENCES:
patent: 4834985 (1989-05-01), Elger et al.
Advances in Prostaglandins, Thromboxane and Leukotriene Research, vol. 13, (1985), pp. 131-139, (Patrono et al.).
Prostaglandins and The Kidney, (1983), pp. 399-406, (Foegh et al.).
The Lancet, 29 Aug. 1981, pp. 433 & 434, (Foegh et al.).
J. Clin. Invest., vol. 76, (1985), pp. 1011-1018, (Patrono et al.).
Clinical Research, vol. 35, (1987), pp. 544A (Ciabattoni et al.).
Am. J. Physiol., 233(5), (1977), pp. H573-H579, (Feigen et al.).
Prostaglandins and The Kidney, (1983), pp. 309-317, (Morrison et al.).
Am. J. Physiol., 248, (1985), pp. F753-F756, (Zipser).
Am. J. Med., vol. 80, (1986), pp. 34-45, (Stork et al.).
Prostaglandins and The Kidney, (1983), pp. 263-274, (Zipser et al.).
Am. J. Med., vol. 81, (1986), pp. 71-83, (Patrono et al.).

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