Use of a thromboxane receptor antagonist in pregnancy-induced hy

Details Use of a thromboxane receptor antagonist in pregnancy-induced hy Use of a thromboxane receptor antagonist in pregnancy-induced hy

1989-06-20

1991-05-14

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

050156489

ABSTRACT:
The use is described of [1R-[1.alpha.(Z),2.beta.,3.beta.,5.alpha.]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid or a physiologically acceptable salt, solvate or cyclodextrin complex thereof in the manufacture of medicaments for the therapy or prophylaxis of conditions associated with vasoconstriction and/or platelet aggregation in the uteroplacental circulation and/or excessive synthesis of thromoxane A.sub.2 in a pregnant female subject.

REFERENCES:
Ghodgaonkar et al., Prostaglandins, Leukotrienes and Medicine, (1987) 26, 33-46.
Van Assche et al., Am. J. Obstet. Gynecol., (1984) 148(2), 216-218.
Miller et al., Am. J. Obstet. Gynecol., (1988) 159(5), 1241-1246.
Keith et al., Am. J. Obstet. Gynecol., (1987) 157(1), 199-203.
Makila et al., Prostaglandins (1984) 27(1), 87-95.
Friedman, Obstet. Gynecol., (1988), 71(1), 122-137.
Elder et al., The Lancet (1988) 1, 410.
Wallenburg et al., The Lancet (1988) 1, 939.
Boura et al., Clinical and Experimental Pharmacology and Physiology (1986) 13, 83-86.
Baxter et al., Br. J. Pharmac. (1989) 96, 71P.
Baxter et al., Poster presented at the second international conference on leukotrienes and prostaglandins in health and disease.
Takagi et al., Advances in Prostaglandin, Thromboxane and Leukotriene Research, 1985, 15, 619-622.
Walsh, Am. J. Obstet, Gynecol., 1985, 152(3), 335-340.

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