Use of a tetrapeptide AcSDKP (SEQ ID No. 1) analog resistant...

Details Use of a tetrapeptide AcSDKP (SEQ ID No. 1) analog resistant... Use of a tetrapeptide AcSDKP (SEQ ID No. 1) analog resistant...

2004-04-28

2009-10-13

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C424S009400, C530S330000

Reexamination Certificate

active

07601333

ABSTRACT:
The invention concerns the use of ACE-resistant N-acétyl-Ser-Asp-Lys-Pro analogues for preparing a reagent or marker adapted to measure a glomerular filtration rate.

REFERENCES:
Junot, Christophe et al.: “Development of an enzyme immunoassay for a stable amidated analog of the hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro”, Journal of Immunoassay and Immunochemistry, vol. 22, No. 1, pp. 15-31, 2001.
Gaudron, Sandrine et al: “NAcSDKP Analogues Resistant to Angiotensin-Converting Enzyme”, Journal of Medicinal Chemistry, vol. 40, pp. 3963-3968, 1997.
Azizi, Michel et al: “Renal and Metabolic Clearance of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) during angiotensin-converting enzyme Inhibition in humans”, Hypertension (Baltimore), vol. 33, No. 3, pp. 879-886, 1999.

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