Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1990-02-06
1992-05-05
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
514912, A61K 37547, A61K 37553
Patent
active
051105900
ABSTRACT:
Preparation and use of a composition of alpha-chymotrypsin in either a physiologically suitable solution or suspension medium, in a dilution of 1:10,000 to 1:30,000, corresponding to a ratio of amounts of 1 milligram of alpha-chymotrypsin to 10 to 30 milliliters of the solution medium, or in a dispersion, by volume, of preferably 1:15,000 to 1:20,000 of the alpha-chymotrypsin to the suspension medium, for the treatment and cleaning of the posterior lens capsule left behind in an extracapsular cataract operation. The composition, in its final application solution or dispersion form contains an amount of a viscoelastic substance adapted for intraocular or intraorbital surgical operations and suitable for combatting or preventing unwanted further dilution of the alpha-chymotrypsin, regardless of the amount of fluids either present or subsequently collected in the eye during the posterior lens cleaning operation.
REFERENCES:
patent: 4695458 (1987-09-01), Krumeich
Lifecore Biomedical--Patents and Copyrights (Abstract).
Sodium Hyaluronate in Anterior Segment Surgery: A Review and a New Use in Extracapsular Surgery (Abstract).
Vitrax Sodium Hyaluronate in Anterior Segment Surgery A Review and Clinical Study Summary (Abstract).
Aq. Solns. of Carboxymethylcellulose or Salts--Used as Ophthalmic Viscoelastic Surgical Material in Anterior Chamber of Eye (Abstract).
Methycellulose for Endothelial Cell Protection (Abstract).
Viscoelastic Soln. Used in Ophthalmic Operations--Comprising HPMC Dissolved in H.sub.2 O in Spec. Conc. for Injection into Lens (Abstract).
Gardner Diane
Poff Clifford A.
Waddell Frederick E.
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