Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-08-01
1997-10-14
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424 59, 424 60, 424400, 424401, A61K 3578, A61K 742
Patent
active
056769482
DESCRIPTION:
BRIEF SUMMARY
The present invention relates essentially to the use of a simarouba extract for the manufacture of a cosmetic or pharmaceutical composition, especially dermatological composition, which has especially a depigmentation activity and an activity promoting keratinocyte differentiation, and which is intended in particular for reducing patchy skin pigmentation, especially liver spots, treating vitiligo, enhancing the protective function of the skin or improving the appearance of the hair, or for the preparation of a skin cell culture medium, and to the composition thus obtained.
More particularly, the invention relates to the use of a simarouba extract for the manufacture of a cosmetic or pharmaceutical composition, especially dermatological composition, which has especially a depigmentation activity as well as an activity promoting keratinocyte differentiation, and which is intended in particular for treating patchy skin pigmentation, especially liver spots, treating vitiligo and skin disorders accompanied by keratinocyte differentiation disorders, such as psoriasis, restoring, preserving and/or enhancing the protective function of the skin, especially the water barrier function, and the cohesion of the epidermal cells, or else improving the quality of the hair, or for the preparation of a cell or tissue culture medium, especially for the mass culture of skin cells, in particular keratinocytes.
The simarouba plant is a plant belonging to the Simaroubaceae family. Among the simarouba plants, there may be mentioned Simarouba amara Aubl., Simarouba glauca, Simarouba versicolor and Simarouba excelsa. These plants are known to have similar properties (see the book by Mrs M. GRIEVE entitled "Modern Herbal", edited by Mrs C. F. LEYEL, published by PENGUIN BOOKS, pages 741-742). Simarouba amara Aubl., in particular, is a fairly widespread tree in Guiana, whose bark is used by the natives as a remedy for treating dysentery, improving the tonicity of the intestine, promoting intestinal secretions and predisposing the patient to sleep.
Furthermore, Chemical Abstracts 110(02)013432 describes the use of Simarouba amara stalk extract for demonstrating an antiamebic activity in vitro. Likewise, Chemical Abstracts 109(101)000285 describes a Simarouba amara fruit extract for the preparation of an antimalarial drug.
Now, the inventors of the present invention have been able to observe that simarouba extracts are particularly active on the melanocytes as regards the inhibition of melanogenesis, and it has been possible to demonstrate this activity by means of in vitro tests on melanocyte cultures, which will be described below. Furthermore, it has been possible to observe that simarouba extracts are also particularly active in promoting keratinocyte differentiation and can thus be used for treating skin disorders accompanied by keratinocyte differentiation disorder. In the epidermis, this differentiation manifests itself in particular by a greater cell cohesion, by a regulation of the transformation of keratinocytes to horny cells through loss of the nucleus and increase in the cell cornification, and by an increase in the number of layers of horny cells forming the stratum corneum, these phenomena together contributing to enhancement of the protective function of the skin against the external environment and to enhancement of the water barrier, which prevents excessive water loss through the epidermis; in the hair follicle, this differentiation manifests itself by a regulation of the processes of keratin synthesis by the keratinocytes, these proteins being the principal constituent of the hair shaft, the quality of which is essential for good hair condition. Moreover, the inventors have been able to observe that these extracts make it possible to promote, accelerate and improve the differentiation of the skin cells, in particular the keratinocytes, when they are cultured in a culture medium.
One object of the present invention is thus to solve the new technical problem which consists in providing a novel formulation of cosmetic
REFERENCES:
patent: 4508703 (1985-04-01), Redziniak et al.
patent: 4621023 (1986-11-01), Redziniak et al.
Bonte Frederic
Dumas Marc
Meybeck Alain
Dodson Shelley A.
LVMH Recherche
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