Use of a simaba extract to reduce patchy skin pigmentation, enha

Details Use of a simaba extract to reduce patchy skin pigmentation, enha Use of a simaba extract to reduce patchy skin pigmentation, enha

1995-08-01

1997-10-14

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

424 59, 424 60, 424400, 424401, A61K 3578, A61K 742

Patent

active

056769490

DESCRIPTION:

BRIEF SUMMARY
The present invention relates essentially to the use of a simaba extract for the manufacture of a cosmetic or pharmaceutical composition, especially dermatological composition, which has especially a depigmentation activity and an activity promoting keratinocyte differentiation, and which is intended in particular for reducing patchy skin pigmentation, especially liver spots, treating vitiligo, enhancing the protective function of the skin or improving the appearance of the hair, or for the preparation of a skin cell culture medium, and to the composition thus obtained.
More particularly, the invention relates to the use of a simaba extract for the manufacture of a cosmetic or pharmaceutical composition, especially dermatological composition, which has especially a depigmentation activity as well as an activity promoting keratinocyte differentiation, and which is intended in particular for treating patchy skin pigmentation, especially liver spots, treating vitiligo and skin disorders accompanied by keratinocyte differentiation disorders, such as psoriasis, restoring, preserving and/or enhancing the protective function of the skin, especially the water barrier function, and the cohesion of the epidermal cells, or else improving the quality of the hair, or for the preparation of a cell or tissue culture medium, especially for the mass culture of skin cells, in particular keratinocytes.
The simaba plant is a plant belonging to the Simaroubaceae family. Among the simaba plants, there may be mentioned Simaba cedron (Planchon), Simaba cuspidata (Spruce), Simaba moretii, Simaba multiflora (Adr. Juss.) and Simaba guyanensis (Aublet Engl.).
These plants are known to have similar properties (see the following books: "Pharmacopees traditionnelles en Guyane" ("Traditional Pharmacopeias in Guiana") by Pierre GRENAND et al., published by ORSTOM, Paris 1987, pages 400-401 and 508-509, and "A Modern Herbal" by Mrs M. GRIEVE, edited by Mrs C. F. LEYEL, published by PENGUIN BOOKS, page 178).
Simaba cedron (Planch.), in particular, is a tree of the forests of Central America, especially Guiana. The natives use the roots of this tree as an anthelmintic or as an antimalarial remedy. They also use the bark as a decoction for the preparation of baths intended for treating skin eruptions of various origins. Finally, the seeds of this tree have long been used as a remedy for snake bites, both by local application to the wound and by ingestion.
Now, the inventors of the present invention have been able to observe that simaba extracts are particularly active on the melanocytes as regards the inhibition of melanogenesis, and it has been possible to demonstrate this activity by means of in vitro tests on melanocyte cultures, which will be described below. Furthermore, it has been possible to observe that simaba extracts are also particularly active in promoting keratinocyte differentiation and can thus be used for treating skin disorders accompanied by keratinocyte differentiation disorder. In the epidermis, this differentiation manifests itself in particular by a greater cell cohesion, by a regulation of the transformation of keratinocytes to horny cells through loss of the nucleus and increase in the cell cornification, and by an increase in the number of layers of horny cells forming the stratum corneum, these phenomena together contributing to enhancement of the protective function of the skin against the external environment and to enhancement of the water barrier, which prevents excessive water loss through the epidermis; in the hair follicle, this differentiation manifests itself by a regulation of the processes of keratin synthesis by the keratinocytes, these proteins being the principal constituent of the hair shaft, the quality of which is essential for good hair condition. Moreover, the inventors have been able to observe that these extracts make it possible to promote, accelerate and improve the differentiation of the skin cells, in particular the keratinocytes, when they are cultured in a culture medium.
One object of the

REFERENCES:
patent: 4508703 (1985-04-01), Redziniak et al.
patent: 4621023 (1986-11-01), Redziniak et al.

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