Use of a pyridazinone derivative

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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A61K31/495

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active

059050780

ABSTRACT:
A method for the treatment of neurohumoral imbalance caused by alterations of cardiac function to prevent the development of heart failure comprises administering an effective amount of mammal in need of such treatment.

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Teikoku Hormone Mfg Ltd, "Novel optically active butyric acid deriv.--obtd. by catalytically hydrogenating butenoic acid derivs., in presence of ruthenium (II) complex(es) for use in pharmaceuticals", Derwent WPI abstract of Japanese Patent Application JP 3163050 published Jul. 15, 1991, Derwent Info Ltd., Week 9134.
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Teikoku Hormone Mgf Co Ltd, "Agent for treating chronic renal failure--contains 6-(4-acetyl-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone", Derwent WPI abstract of Japanese Patent Application JP 4368328 published Dec. 21, 1992, Derwent Info Ltd., Week 9314.
Myasaka, K. et al., "A pyridazinone for treatment of chronic heart failure", Chemical Abstracts abstract of Japanese Patent Application JP 4368328 published Dec. 21, 1992, CA 118:198216.
Ishimori, T. et al., "Cardiac Effects of the Novel Pyridazinone Derivative mino!-4,5-dihydro-5-methyl-3(2H) pyridazinone Monoethyl Maleate and Its Metabolite in Isolated Heart Preparations of Guinea Pigs and Dogs", Arzneim.-Forch. /Drug Res. 44(1), Nr. 5, 1994, 583-588.

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