Use of a pregnane derivative

Details Use of a pregnane derivative Use of a pregnane derivative

1994-12-19

1996-04-30

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514169, 514182, A61K 3156

Patent

active

055125565

ABSTRACT:
The invention relates to a use of pregnane derivatives of the following general formula: ##STR1## in which R=H.sub.2, (H,OH), (H,OAcyl), or O, and especially the pregnane derivative(7.alpha.,17.alpha.)-17-hydroxy-7-methyl-19-nor -17-pregn-5(10)-en-20-yn-3-one (compound I), for the manufacture of a medicament for the prevention or treatment of tumors.

REFERENCES:
R. Smith et al., "Hormone Replacement Therapy: A Review", Journal of Drug Development, vol 4, No. 4, pp. 235-344, 1992.
L. Markiewicz et al., "In Vitro Evaluation of Estrogenic, Estrogen Antagonistic and Progestagenic Effects of a Steroidal Drug (Org OD-14) and its Metabolites on Human Endometrium" The Journal of Steroid Biochemistry vol. 35, No. 5, Apr. 1990, pp. 535-541.

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