Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-02-02
1998-01-27
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 424426, 424428, A61F 1300
Patent
active
057119570
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The subject of the invention is the use of a calcium carbonate based material as support for a growth factor in the preparation of a bioabsorbable implant intended to be fitted in a living organism.
Such a material can be used, in particular, as a bone-formation implant.
BACKGROUND
It is known that bone surgery often requires the fitting of bone grafts or implants constituting artificial replacements for such grafts.
Carrying out allografting raises objections, for obvious reasons of public health, in view of the risks of transmission of certain serious viral illnesses or illnesses caused by unconventional transmittable agents or "prions".
From this point of view, carrying out autografting is more satisfactory, but taking the graft leads to significant risks of morbidity; see, for example, Christopher J. Damien and J. Russell Parsons, Journal of Applied Biomaterials, Vol. 2, 187-208 (1991).
For these reasons, it has been recommended to use implants based on biocompatible materials such as tri-calcium phosphate, hydroxyapatite, plaster, coral, polymers based on poly(lactic acid) and/or poly(glycolic acid), etc.
Some of these materials, including calcium carbonate, are bioabsorbable and allow the progressive formation of newly formed bone tissue at the expense of the implanted material being absorbed; see especially European Patent 0,022,724.
It is moreover known that the presence of certain osteoinductive factors in the implants promotes bone regrowth. However, specialists have until now judged it to be necessary to add to the implant collagen acting as a support for the osteoinductive factors; see in this context the article by Damien and Russell Parsons already cited hereinabove and Patent Application FR-2,637,502.
SUMMARY OF THE INVENTION
It has now been discovered that a porous calcium carbonate based material such as coral can act as a support for osteoinductive factors, and more generally for growth factors, in the preparation of bioabsorbable implants and that the presence of collagen is neither necessary nor desirable in the case when the implant is intended to be used as a bone-formation implant.
DESCRIPTION OF PREFERRED EMBODIMENTS
The subject of the present invention is therefore the use of a porous calcium carbonate based material as support for at least one growth factor in the preparation of a bioabsorbable implant intended to be fitted in a living animal organism, in particular in a vertebrate, including humans, the said support being free of collagen in the case when the said growth factor is an osteoinductive factor.
When the growth factors are osteoinductive factors, the implants can be used as bone-formation implants. Of course, these implants may contain, in addition to the osteoinductive factors, other growth factors. The implants thus obtained can either be fitted as bone fillers which can be absorbed progressively in favour of newly formed tissue or implanted in a non-osseous site, for example connective tissue, where they give rise to bone tissue which can subsequently be used as a bone autograft material.
When the calcium carbonate support is loaded with a non-osteoinductive growth factor, it can be used in particular as a support for in vivo culture of living cells. Depending on the cells and the growth factors used, the implant, after fitting, may be used in particular as a support for obtaining tissue newly formed on the implantation site. This newly formed tissue can be used as a replacement for defective organ parts (pancreas/intestine connection, urethra, bladder, pericardium, etc.).
The implant of the invention can also be used as an in vivo culture support for cells which have been genetically modified, especially by insertion of a suitable gene, in a manner which is known per se, in order to remedy a genetic defect. The modified cells may also come from autologous sampling. The implants thus obtained constitute an "organoid" serving as a therapeutic treatment device, fitting of which makes it possible to make up for a defective organ, and in
REFERENCES:
patent: 4563350 (1986-01-01), Nathan
patent: 4917702 (1990-04-01), Scheicher et al.
patent: 5240710 (1993-08-01), Bar-Shalom et al.
patent: 5264214 (1993-11-01), Rhee et al.
Damien, C. J. et al., "Bone Graft and Bone Graft Substitutes: A Review of Current Technology and Applications," J. Applied Biomaterials, vol. 2, 187-208 (1991).
Journal of Cellular Biochemistry, Supplement 15F, 1-7 Apr. 1991 Abstract CF15, ed. Wiley-Liss, P. Moullier et al. "Organoid Neovascular Structure: Effects of Various Matrix and Angiogenic Factors".
Medicine Sciences, vol. 9, No. 2, Feb. 1993, pp. 208-210, O. Danos "Reimplantation de cellules genetiquement modifiees dans des neo-organes vascularises," ed. John Libbey Eurotext.
Ouhayoun Jean-Pierre
Patat Jean-Louis
Howard Sharon
Inoteb
Page Thurman K.
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