Use of a polypeptide for treatment of pruritus in animals

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S070140

Reexamination Certificate

active

06969590

ABSTRACT:
The present invention is directed to a treatment for animal pruritus. One aspect of this invention involves a treatment for animal pruritus comprising one or more polypeptides with an amino acid sequence including KPV (SEQ ID NO: 1), VKP-Ac-CC-Ac-KPV (SEQ ID NO: 5), MEHFRWG (SEQ ID NO: 2), HFRWGKPV (SEQ ID NO: 3) or SYSMEHFRWGKPV (SEQ ID NO: 4) for animal pruritus caused by exposure to any number of agents or causes. The polypeptides are at a level to effectively treat the animal pruritus and are combined with a shampoo. Other combinations include the polypeptides at a level to effectively treat animal pruritus combined with a shampoo and an antibiotic, antifungal and/or and anti-inflammatory. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above.

REFERENCES:
patent: 5028592 (1991-07-01), Lipton
patent: 5157023 (1992-10-01), Lipton
patent: 5739111 (1998-04-01), Mahe
patent: 5972962 (1999-10-01), Belfield et al.
patent: 6001812 (1999-12-01), Mahe
patent: 2003/0113284 (2003-06-01), Dalko et al.
patent: WO 93/01211 (1993-01-01), None
patent: WO 00/56353 (2000-09-01), None
patent: WO 00/59527 (2000-10-01), None
Barcellini, W. et al., “Inhibitory Influences of α-MSH Peptides on HIV-1 Expression in Monocytic Cells.”12thWorld AIDS Conference Geneva,Abstract No. 60685, Jun. 28-Jul. 3 (1998).
Barcellini W. et al., “α-MSH Peptides Inhibit HIV-1 Expression in Chronically Infected Promonocytic U1 Cells and in Acutely Infected Monocytes.”Journal of Leukocyte Biology68:693-699 (2000).
Barnes, P. et al., “Nuclear-Factor-KB—A Pivotal Transcription Factor in Chronic Inflammatory Diseases.”New England J. Med.336: 1066-1071 (1997).
Bazzani, C. et al., “Protective Effect of Melanocortin Peptides in Rat Myocardial Ischemia.”J. Pharmacol. Exp. Ther.297: 1082-1087 (2001).
Benigni, A. et al., “Endothelin Antagonists.”Lancet353: 133-138 (1999).
Bhattacharya A. et al., “Effect of Cyclic AMP on RNA and Protein Synthesis inCandida albicans.” Biochem, Biophysics. Res. Commun.77: 1438-44 (1977).
Capsoni, F. et al., “Effect of Corticosteroids on Neutrophil Function: Inhibition of Antibody-dependent Cell-Mediated Cytotoxicity (ADCC).”J. Immunopharmacol.5: 217-30 (1983).
Cartledge, J.D. et al., “Clinically Significant Cross-Resistance in Candida Isolates from HIV-Positive Patients with Oral Candidosis.”AIDS11: 1839-44 (1997).
Catania, A. et al., “α-Melanocyte Stimulating Hormone in Modulation of Host Reactions.”Endocr. Rev.14: 564-576 (1993).
Catania A. et al., “α-Melanocyte-Stimulating Hormone Peptides in Host Responses: from Basic Evidence to Human Research.”Annals of the New York Academy of Sciences680: 412-423 (1993).
Catania A. et al., “α-MSH in Normal Human Physiology and Disease States.”Trends Endocrinol. Metab.11: 304-308 (2000).
Catania A. et al., “α-MSH in Systemic Inflammation: Central and Peripheral Actions.”Annals of the New York Academy of Sciences885: 183-187 (1999).
Catania A. et al., “Cytokine Antagonists in Aged Subjects and Their Relation with Cellular Immunity.”Journal of Gerontology: Biological Sciences52A: B93-97 (1997).
Catania A. et al., “Cytokine Antagonists in Infectious and Inflammatory Disorders.”Annals of the New York Academy of Sciences741: 149-161 (1994).
Catania, A. et al., “Melanocortin Peptides Inhibit Production of Proinflammatory Cytokines in Blood of HIV-Infected Patients.”Peptides19(6): 1099-1104 (1998).
Catania A. et al., “Plasma Concentrations and Anti-L-Cytokine Effects of α-Melanocyte-Stimulating Hormone in Septic Patients.”Crit. Care Med. 28:1403-1407 (2000).
Catania A. et al., “Plasma Concentration of Cytokine Antagonists in Patients with HIV Infection.”Neuroimmunomodulation1: 42-49 (1994).
Catania A. et al., “Proopiomelanocortin-Derived Peptides and Cytokines: Relations in Patients with Acquired Immunodeficiency Syndrome.”Clinical Immunology and Immunopathology66: 73-79 (1993).
Catania, A. et al., “The Neuropeptide α-MSH in HIV Infection and Other Disorders in Humans.”Ann. N.Y. Acad. Sci.840: 848-856 (1998).
Catania, A. et al., “The Neuropeptide α-MSH has Specific Receptors on Neutrophils and Reduces Chemotaxis in Vitro.”Peptides17: 675-679 (1996).
Ceriani, G. et al., “Central Neurogenic Antiinflammatory Action of α-MSH: Modulation of Peripheral Inflammation Induced by Cytokines and other Mediators of Inflammation.”Neuroendocrinology59: 138-143 (1994).
Ceriani G. et al., “The Neuropeptide Alpha-Melanocyte-Stimulating Hormone Inhibits Experimental Arthritis in Rats.”Neuroimmunomodulation1: 28-32 (1994).
Chiao, H. et al., “60 -Melanocyte-Stimulating Hormone Protects Against Renal Injury After Ischemia in Mice and Rats.”J. Clin. Invest.99: 1165-1172 (1997).
Chiao H. et al., “α-MSH Reduces Endotoxin-Induced Liver Inflammation.”J. Clin. Invest.97: 2038-2044 (1996).
Chomczynski, P. et al., “Single-step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction.”Anal. Biochem.162: 156-159 (1987).
Cooper, M. et al., “Myocardial Nuclear Factor-κB Activity and Nitric Oxide Production in Rejecting Cardiac Allografts.”Transplantation66: 838-844 (1998).
Csato, M. et al., “Enhancement ofCandida albicanskilling activity of separated human epidermal cells by alpha-melanocyte stimulating hormone.”British Journal of Dermatology121(1): 145-147 (1989).
Cutuli, M. et al., “Antimicrobial effects of α-MSH peptides.”Journal of Leukocyte Biology67: 233-239 (2000).
Deeter, L.B. et al., “Antipyretic Properties of Centrally Administered α-MSH Fragments in the Rabbit.”Peptides9: 1285-1288 (1989).
Delgado, R. et al., “Melanocortin Peptides Inhibit Production of Proinflammatory Cytokines and Nitric Oxide by Activated Microglia.”Journal of Leukocyte Biology63: 740-745 (1998).
DeVries, M. et al., “On the Edge: The Physiological and Pathophysiological Role of Chemokines During Inflammatory and Immunologic Responses.”Semin. Immunol.11: 95-104 (1999).
Eberle, A. et al., “Hormone-Receptor Interactions.”Clinical Endocrinology 5,Supp., 41s-48s (1976).
Eberle, A. et al., “The Melanotrophins.”Karger, Basel, Switzerland(1988).
Fairchild, R. et al., “Chemokines and the Recruitment of Inflammatory Infiltrates Into Allografts.”Graft3: s24-s31 (2000).
Fauci, A.S., “Host Factors in the Pathogenesis of HIV-induced Disease.”Nature384: 529 (1996).
Feeley, B.T. et al., “Nuclear Factor-κB Transcription Factor Decoy Treatment Inhibits Graft Coronary Artery Disease After Cardiac Transplantation in Rodents.”Transplantation70: 1560-1568 (2000).
Getting et al., “POMC Gene-Derived Peptides Activate Melanocortin Type 3 Receptor on Murine Macrophages, Suppress Cytokin Release, and Inhibit Neutrophil Migration in Acute Experimental Inflammation.”J. Immunol.vol. 162, No. 12, pp. 7446-7453 (1999).
Gow, N.A., “Germ Tube Growth ofCandida albicans.” Curr. Topics Med. Myco.8: 43-55 (1997).
Grabbe, S. et al., “α-Melanocyte-Stimulating Hormone Induces Hapten-Specific Tolerance in Mice.”J. Immunol.156: 473-478 (1996).
Harris et al., “Alpha-Melanocyte Stimulating Hormone (a-MSH) and Melanin-Concentrating Hormone (MCH) Stimulate Phagocytosis by Head Kidney Leucocytes of Rainbow Trout (Oncorhynchus mykiss) in vitro.”Fish&Shell Immunol.,vol. 8, 8:631-638 (1998).
Hart, D.A. et al., “Staphylococcus aureusStrains Differ in Their in Vitro Responsiveness to Human Urokinase: Evidence that Methicillin-Resistant Strains are Predominantly Nonresponsive to the Growth-Enhancing Effects of Urokinase.”Can. J. Mi

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of a polypeptide for treatment of pruritus in animals does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of a polypeptide for treatment of pruritus in animals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of a polypeptide for treatment of pruritus in animals will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3505329

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.