Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-02-28
1999-06-15
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530308, 530324, A61K 3826, C07K 14605
Patent
active
059122293
ABSTRACT:
The present invention relates to appetite-suppressing peptides or an appetite-suppressing peptide-containing fraction for the treatment of obesity or type II diabetes.
REFERENCES:
patent: 5545618 (1996-08-01), Buckley et al.
patent: 5635564 (1997-06-01), Wieditz et al.
M.D. Turton et al., Nature vol. 379, pp. 69-72, (Jan. 1996).
J. Rachman et al., Diabetic Medicine, vol. 12, pp. 467-478 (1995).
Drucker et al., Proc. Natl. Acad. Sci. USA, vol. 93, pp. 7911-7916 (Jul. 1996).
Buhl et al., `Natrually Occurring Products of Proglucagon 111-160 in Porcine and Human Small Intestine`, The Journal of Biological Chemistry, vol. 263, No. 18, pp. 8621-8624, 1988.
Schmidt et al. `Glucagon-Like Peptide-1 but not Glucagon-Like Peptide-2 Simulates Insulin Release from Isolated Rat Pancreatic Islets`, Diabetolgia, vol. 28, No. 9, (abstract only), 1985.
Komatsu et al., `Effect of Glucagon-Related Peptides on Rat Endocrine Pancreas`, vol. 9, Suppl. 3, pp. 201-206 (abstract), 1988.
Mommsen et al. `Glucagon-Like Peptides Activate Hepatic Gluconeogenesis`, vol. 219, No. 1, pp. 227-232, 1987.
The Merck Manual, Sixth Edition, published 1992 by Merck Research Labratories, pp. 1108-1109, 1992.
Holst Jens Juul
Judge Martin Edward
Madsen Ole Dragsbaek
Thim Lars
Wulff Birgitte Schjellerup
Gupta Anish
Lambiris, Esq. Elias J.
Novo Nordisk Als
Tsang Cecilia J.
Zelson Esq. Steve T.
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