Use of a peptide that interacts with αvβ3...

Details Use of a peptide that interacts with αvβ3... Use of a peptide that interacts with αvβ3...

2011-04-05

2011-04-05

Tsang, Cecilia (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200

Reexamination Certificate

active

07919464

ABSTRACT:
The present invention relates to the use of a peptide that interacts with the αvβ3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (TY) or asparagines-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.

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Kim et al., “Identification of Motifs in the Fasciclin Domains of the Transforming Growth Factor-β- induced Matrix Protein βig-h3 That Interact with the αvβ5 Integrin,”The Journal of Biological Chemistry, 2002, vol. 277, n. 48, The American Society for Biochemistry and Molecular Biology, Inc., Washington, D.C.
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