Use of A-Nor-steroids as malignant cells growth inhibitors

Details Use of A-Nor-steroids as malignant cells growth inhibitors Use of A-Nor-steroids as malignant cells growth inhibitors

1989-05-10

1991-03-19

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514729, 560194, 568817, A61K 3156, C07J 6100

Patent

active

050011200

ABSTRACT:
A-Nor-5.alpha.-androstane compounds, such as the dipropionate and disuccinate esters of 2.alpha.,17.alpha.-diethynyl-A-Nor-5.alpha.-androstane-2.beta.,17.beta.-di ol and the corresponding 2.alpha.,17.alpha.-diol stereoisomers have an inhibitory effect on malignant cell growth and can be used to treat various carcinomas in mammals.

REFERENCES:
patent: 4898694 (1990-02-01), Schwartz et al.
Pincus et al., "Steroidal Inhibitors of a Cell-Division-Inducing System In Vitro", Steroids 5 (Supl. I), pp. 193-197, (1965).

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