Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1986-11-21
1990-06-12
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 691, 435 695, 4352528, 4351723, 435320, 935 23, 935 38, 935 48, 536 27, C12N 120, C12N 122, C12P 2100, C12P 2106, C07H 1512
Patent
active
049332880
ABSTRACT:
DNA sequences encoding proteins processable by secretion leaders in recombinant hosts are described. The DNA sequences encode the NH.sub.2 -terminal region of proteins that are cleaved from a secretion leader and may be secreted through the cell membrane and, if present, cell wall in some cases. Proteins encoded by the DNA sequence have an NH.sub.2 -terminal amino acid sequence conforming to a consensus amino acid sequence that is processable by the particular secretion leader. DNA sequences encoding a consensus amino acid sequence processable by the diphterhia toxin secretion leader are disclosed. A novel Pseudomonas exotoxin and CSF-1 having NH.sub.2 -terminal sequences conforming to a consensus sequence are exemplified.
REFERENCES:
Gray et al., PNAS81 (1984), pp. 2645-2649.
Kaczorek et al., Science (1984), vol. 221, pp. 835-858.
Kawasaki et al., Science (1985), vol. 230, pp. 291-296.
Carson Patricia
Cetus Corporation
Fineman Elliott L.
Giotta Gregory J.
Halluin Albert P.
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