Use of a mixture of two or more enteric materials to...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

Reexamination Certificate

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C424S471000, C424S464000, C424S468000

Reexamination Certificate

active

07910128

ABSTRACT:
Disclosed are pharmaceutical compositions, particularly oral dosage forms, which comprise two or more enteric coating materials, either as a coating or as part of a matrix dosage form, and methods of making and using the same. The compositions are characterized by having a sustained release profile at lower pH and an accelerated dissolution profile at higher pH.

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Khan et al., “A PH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers—Manipulation of drug release using Eudragit® S100 combinations,” Journal of Controlled Release, Mar. 29, 1999, 58(2):215-222.

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