Use of a low affinity-heparin fraction in conjunction with t-PA

Details Use of a low affinity-heparin fraction in conjunction with t-PA Use of a low affinity-heparin fraction in conjunction with t-PA

1988-11-04

1992-07-14

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 544 56, 435178, 435219, 435226, 536 21, A61K 37547, A61K 31725, C12N 1104, C08B 3710

Patent

active

051301431

ABSTRACT:
A composition for thrombolytic therapy includes a tissue-type plasminogen activator (t-PA) and a low affinity heparin fraction. The composition is administered intravenously to allow the t-PA to dissolve blood clots while the low affinity heparin fraction prevents reocculsion without the harmful side effects observed for unfractionated heparin, such as, stimulation of and interference with t-PA activity in the circulatory system, as well as, interference with fibrinolytic activity which can cause hemorrhaging in the mammalian circulatory system.

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