Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-29
2011-12-27
Anderson, James D (Department: 1629)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S407000
Reexamination Certificate
active
08084455
ABSTRACT:
The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.
REFERENCES:
patent: WO 2005/005427 (2005-01-01), None
Carter T.A. et al., “Inhibition of Drug-Resistant Mutants of ABL, KIT, and EGF Receptor Kinases”,Proceedings of the National Academy of Sciences 102(31):11011-11016 (2005), XP-002440841.
Gumireddy K. et al., “A Non-ATP-Competitive Inhibitor of BCR-ABL Overrides Imatinib Resistance”,Proceedings of the National Academy of Sciences 102(6):1992-1997 (2005), XP-002405719.
Fancelli Daniele
Isacchi Antonella
Lupi Rosita
Modugno Michele
Moll Juergen
Anderson James D
Nerviano Medical Sciences S.r.l.
Scully , Scott, Murphy & Presser, P.C.
LandOfFree
Use of a kinase inhibitor for the treatment of particular... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of a kinase inhibitor for the treatment of particular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of a kinase inhibitor for the treatment of particular... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4306496