Use of a high molecular weight extracellular hemoglobin for...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C514S006900, C424S009100

Reexamination Certificate

active

07999076

ABSTRACT:
The present invention relates to the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing diseases by inhibition of calcium. Advantageously, the extracellular hemoglobin is obtained from Annelids. In particular, the invention concerns the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing cardiovascular diseases, such as hypertension, angina such as angina pectoris, Raynaud's disease, arteriopathy, tachycardia, vasospasm, ischemia, myocardial infarction, congestive heart failure, arrhythmia or cerebrovacular accident.

REFERENCES:
patent: 2003/0181358 (2003-09-01), Zal et al.
Paul A. Meglitsch, “Invertebrate Zoology”, second edition, pp. 364-427, (1972).
Katy Lìsias Gondim Dias et al., “Cardiovascular Effects Induced by Reticuline in Normotensive Rats”, Planta Med, vol. 70, Jan. 25, 2004, pp. 328-333.
Gordon S. Stokes, MD, FRACP, “Systolic Hypetension in the Elderly: Pushing the Frontiers of Therapy A Suggested New Approach”, vol. VI, No. IV, Apr. 2004, pp. 192-197.
Ryan P. Jewell, M.D. et al., “Inhibition of Ca ++ sparks by oxyhemoglobin in rabbit cerebral arteries”, J. Neurosurg., vol. 100, Feb. 2004, pp. 295-302.
Roberto Fogari et al., “Effect of Antihypertensive Agents on Quality of Life in the Elderly”, Drugs Aging, vol. 21, No. 6, 2004, pp. 377-393.

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