Use of a direct-acting thrombin inhibitor for the manufacture of

Details Use of a direct-acting thrombin inhibitor for the manufacture of Use of a direct-acting thrombin inhibitor for the manufacture of

1995-02-13

1996-12-10

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514166, A61K 3800, A01N 3736, A61K 31615

Patent

active

055831133

ABSTRACT:
A method for inducing thrombolysis, which method comprises administering to a patient a thrombolytically effective amount of a thrombin inhibitor which acts at the active site of thrombin, in the absence of exogenous plasminogen activator. The inhibitor is preferably argatroban, D-Phe-Pro-Arg-chloromethyl ketone, or Ac-(D-Phe)-Pro-boro-Arg-OH.

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A. Chiu et al., "Inhibition of the thrombin-platelet reactions by DuP 714", Biochemical & Bio-Physical Research Communications, vol. 179, No. 3, Sep. 30, 1991, pp. 1500-1508.
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Kikumoto et al., Biochem, vol. 23, pp. 85-90, 1984.
Schneider, Thrombosis Research vol. 64, p. 677 (1991).
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