Use of a derivatized alkaline phosphatase as a standard

Details Use of a derivatized alkaline phosphatase as a standard Use of a derivatized alkaline phosphatase as a standard

1992-04-16

1993-09-28

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 435 21, 435188, 435196, 435967, 436827, C12Q 142, G01N 33566

Patent

active

052485927

ABSTRACT:
Alkaline phosphatase to which is covalently bound a carbohydrate of the general formula ##STR1## wherein n is 0, 1, 2 or 3, A is an acyl radical containing 2 to 5 carbon atoms, R.sup.1 and R.sup.2 are each hydrogen atoms or hydroxyl groups, R.sup.3 is --COOH or --CH.sub.2 OH, R.sup.4 is a hydroxyl group or a --CHOH--CHOH--CH.sub.2 OH or --NH--CO--CH.sub.2 --CH(NH.sub.2)--COOH radical or a complex containing the carbohydrate, is used as a standard for the determination of human alkaline phosphate. Preferred carbohydrates are ovomucoid, chitobiose, chitotriose or N-acetylglucosamine-N-acetylneuraminic acid.

REFERENCES:
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W. Behr et al., Arztl. Lab 32:159-165 (1986) (English translation).
Stowoll et al. Advances in Carbohydrate Chemistry and Biochemistry 37:225, 1980.
F. G. Lehmann (1980) Klin. Wochenschr. 58:947-951.
Donald W. Moss (1982) Clin. Chem. 28/10:2007-2016.
Yamamoto, K. et al. Biochem. 20:5894, 1981.
Onica, D. et al. Clin. Chim. Acta 155:285, 1986.

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