Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-11-27
1998-12-08
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530328, A61K 3808
Patent
active
058469397
ABSTRACT:
The present invention relates to the use of the decapeptide having the amino acid sequence of SEQ ID NO.:1 ##STR1## in the preparation of medicines having benzodiazepine-type activity, particularly useful for the treatment of convulsions and anxiety. The invention also relates to phamaceutical compositions, food supplements, and foodstuffs for special diets containing the said decapeptide.
REFERENCES:
patent: 5208240 (1993-05-01), Peet et al.
Minawawa et al. `Dibittering mechanism in bitter peptides of enzymatic hydrolysates from milk casein by aminopeptidase T`, J. of Food Sci., 54(5), pp 1225-1229 Oct. 1989.
Shon et al. `Antibodies raised against peptide fragments of bovine s1--casein cross-react with the native protein, but recognize sites distinct from the determinants on the protein`, Eur. J. Immunol., 21, pp. 1475-1480 1991.
Yan et al., `Purification and characterization of a novel metalloendopeptidase from Steptococcus cremoris H61`, Eur. J. Biochem. 163, pp. 259-265 1987.
Niles et al., `Pharmacological inhibition fo Forskolin-stimulated adenylate cyclase activity in rat brain melatonin, its analogs, and diazepam.` Biochem. Pharmac., 40(12), pp. 2701-2705 1990.
Loukas et al. `Opioid acivities and structures of -Casein-Derived Exophins.` Biochemistry, 22, 4567-4573 1983.
Copy of European Search from French patent94/14362, filed Nov. 30, 1994 with cited references.
Boudier Jean-Fran.cedilla.ois
Driou Alain
Iung Catherine
Linden Guy
Miclo Laurent
Gupta Anish
Societe Cooperative Agricole Laitiere D'Artois Et Des Flandres,
Tsang Cecilia J.
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