Use of a compound antagonist of ESM-1 protein for producing...

Details Use of a compound antagonist of ESM-1 protein for producing... Use of a compound antagonist of ESM-1 protein for producing...

2007-12-11

2007-12-11

Foley, Shanon (Department: 1642)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S141100, C424S277100

Reexamination Certificate

active

10416203

ABSTRACT:
Use of an antagonist compound of protein ESM-1 for the production of a drug for the treatment of a cancer.

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Bechard et al., J Vasc Res, vol. 37, pp. 417-425, Apr. 2000.
U.S. Appl. No. 10/416,204, filed May 8, 2003, Lassalle et al.
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International Search Report in corresponding PCT/FR01/03475.
Bechard et al.; Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies; J. Vasc. Res. (2000) 37:417-425.
Lassalle et al.; ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines; J. Biol. Chem. (1996) vol. 271, No 34 pp. 20458-20464.
Hendrix et al.; Expression of select-endothelial-specific genes by aggressive human melanoma cells: Putative role of VE-Cadherin (CD144) in vasculogenic mimicry; FASEB Journal, vol. 15, No. 5 (2001) p. A743 XP001015835.

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