Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-06-25
2000-11-28
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514813, A61K 3144
Patent
active
061536296
DESCRIPTION:
BRIEF SUMMARY
The invention generally relates to a combination of an anti-smoking composition such as a nicotine-releasing agent and a dietary composition and use of this combination in smoking cessation and/or a cure of nicotine addiction. There is also provided a method of curing an individual of nicotine dependence and a kit comprising an anti-smoking composition in the form of a nicotine-releasing agent in combination with a dietary composition.
BACKGROUND OF THE INVENTION
Medical evidence has established that cigar and pipe smoking cause cancer of the oral cavity and that cigarette smoking is directly linked to lung cancer. Smokeless tobaccos such as chewing tobacco and snuff have also been associated with increased risks of cancer of the oral cavity. In many countries today, as many as one third of all cancer deaths can be attributed to cigarette smoking. Smoking also increases the risks of contracting diseases of the heart and lungs. This is due to the fact that tobacco smoke has a high content of hazardous particles, including nicotine, a high content of carbonmonooxid (CO) and a high content of tar, all of which seriously affect the proper functioning of both airways and lungs. It has been shown that regular smoking over a prolonged period of time leads to an increased risk of diseases of the airways, such as e.g. chronic bronchitis.
Nicotine is an alkaloid and one of many poisonous substances contained in tobacco. Nicotine is generally regarded as being addictive and generates a mild narcotic effect. Other well known alkaloids are e.g. cocaine, morphine and strychnine.
Nicotine is a serious health hazard and has a contracting effect on the vascular system as it constricts the blood vessels and leads to a raised blood pressure. These effects put a strain on the heart function. It is not known for certain if nicotine alone, or in combination with one or more of the more than four thousand different substances present in tobacco, causes the long-term health hazards associated with tobacco smoking and/or use of tobacco. "Use of tobacco" when used herein should be understood to comprise all aspects of tobacco use leading to an intake of nicotine, be it through smoking or otherwise. Consequently, the tobacco may be in the form of tobacco for use in a cigarette, a cigar, pipe tobacco, chewing tobacco, snuff and the like.
It is well known that tobacco suppresses the appetite and accordingly, many people use tobacco as an aid in weight control. As a consequence hereof, many people wishing to stop smoking often experience that a tobacco use cessation is associated with an undesirable weight gain that may easily counteract the otherwise positive effects associated with a non-smoking life-style. The conventional "anti-smoking compositions" available on the market often do not adequately take into account the undesirable effects of a weight gain associated with the unaided decision to stop smoking or the deliberate participation in a cure of nicotine dependence.
"Anti-smoking composition" in the context used above should be understood as a composition generally intended for helping an individual to stop smoking. Examples of such "anti-smoking composition" are listed on pages 822-823 of the Danish Drug Catalogue (1997). The composition may be in the form of a nicotine-releasing agent such as a nicotine-containing chewing gum or a nicotine patch. The term "anti-smoking composition" is thus used to describe nicotine-releasing agents for use by an individual in locations where smoking is prohibited as well as nicotine-releasing agents used as a substitute for nicotine-containing tobacco during a cure of nicotine dependence.
The provable connection between tobacco use and the numerous health hazards associated therewith has led many people, especially smokers, to decide quitting the habit and stop using tobacco. The statistics are very convincing: More than 80% of all smokers express a desire to stop smoking, and each year 35% try to stop smoking, but less than 5% are successful in unaided attempts to quit the habit. (Americ
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Cooper Iver P.
Jordan Kimberly
Nutri Pharma ASA
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