Use of a COL1A1 mini-gene construct to inhibit collagen synthesi

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4351723, 4353201, 435325, 536 235, 536 245, A61K 4800, C07H 2104, C12N 1512, C12N 1585

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057863415

ABSTRACT:
Methods are provided for controlling the synthesis of protein from the human gene for the pro.alpha.1(I) chain of type I procollagen in cells using mini-gene constructs which are injected into cells which synthesize the protein. Methods for controlling collagen deposition in tissue mini-gene constructs are also provided.

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