Use of a carboxy-substituted polymer to inhibit plaque formation

Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing

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424 49, 424 55, A61K 716, A61K 718, A61K 724

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active

050931709

ABSTRACT:
The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR1## or the salts thereof, wherein R is a C.sub.1 -C.sub.8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the tooth surfaces which are contacted with the composition.
This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-substituted polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-substituted polymer to the tooth surface. The application does not stain the teeth on which it is made.

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"Report on the Use of Triclosan/Copolymer Dentifrices in the Control of Plaque and Gingivitis", Am. J. Dent. 2: 181-240, 1989.

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