Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1990-05-21
1991-04-23
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
424 48, 514778, A61K 716, A61K 718, A61K 968
Patent
active
050098829
ABSTRACT:
The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a plaque-inhibiting carboxy starch polymer comprising the formula ##STR1## wherein W and X are independently selected from CH.sub.2 OH, CHO and CO.sub.2 H, or the neutralized carboxylic acid salts thereof, Y and Z are independently selected from CHO and CO.sub.2 H, or the neutralized carboxylic acid salts thereof, n is in the range of from about 5 to about 2500, m is in the range of from 0 to about 2500, provided that the sum of n and m ranges from about 5 to about 2500, and the degree of carboxylation of said active agent ranges from about 1 to about 3; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the teeth which are contacted with the composition.
This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy starch polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy starch polymer to the oral cavity. The application does not stain the teeth on which it is made.
REFERENCES:
patent: 3665000 (1972-05-01), Hills et al.
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patent: 3719514 (1973-03-01), Taylor
patent: 3784475 (1974-01-01), Diehl
patent: 4004039 (1977-01-01), Shoaf et al.
patent: 4673704 (1987-06-01), Flesher et al.
patent: 4778836 (1988-10-01), Farrar et al.
Degenhardt Charles R.
Kozikowski Barbara A.
Lewis L. W.
Rose Shep K.
The Proctor & Gamble Company
Witte R. C.
Yetter J. J.
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