Use of a bioadhesive composition comprising a polyphenolic...

Details Use of a bioadhesive composition comprising a polyphenolic... Use of a bioadhesive composition comprising a polyphenolic...

2005-03-15

2005-03-15

Wax, Robert A. (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C524S017000, C524S025000, C524S021000, C523S112000, C523S118000

Reexamination Certificate

active

06867188

ABSTRACT:
A non-irritating, non-allergenic and non-toxic bioadhesive composition can be obtained by providing a bioadhesive composition including a polyphenolic protein derived from byssus-forming mussels and, b) a polymer comprising carbohydrate groups. The bioadhesive composition does not contain any enzyme or chemical cross-linking agent. Optionally, the composition may contain an oxidising agent and/or a filler protein. Preferably, the composition is provided as a kit of at least two parts, namely the polyphenolic protein and the polymer comprising carbohydrate groups, respectively. The composition is especially suitable as an adhesive in ophthalmic therapy.

REFERENCES:
patent: 5015677 (1991-05-01), Benedict et al.
patent: 5030230 (1991-07-01), White
patent: 5078744 (1992-01-01), Chvapil
patent: 8803953 (1988-06-01), None
patent: 9428937 (1994-12-01), None
C. Benedict et al. Chapter 33, “Adhesives from Marine Mussels”, ACS Symp. Ser. (1989), 385 (Adhes. Renewable Resour.) pp. 465-483.
J. Waite et al., “Polyphenolic Substance ofMytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline”, SCIENCE, vol. 212, May 1981, pp. 1038-1040.
T. Deming, “Mussel byssus and biomolecular materials”, Current Opinion in Chemical Biology, vol. 3., 1999, pp. 100-105.
M. Yu et al., “Synthetic Polypeptide Mimics of Marine Adhesives”, Macromolecules, vol. 31, 1998, pp. 4739-4745.
J. Waite, “Mussel glue fromMytilus californianusConrad: a comparative study”, J. Comp Physiol B., vol. 156, 1986, pp. 491-496.
R. Strausberg et al., “Protein-based medical adhesives”, TIBTECH, vol. 8, 1990, pp. 53-57.
Jeffrey B. Robin et al., “Preliminary Evaluation of the Use of Mussel Adhesive Protein in Experimental Epikeratoplasty,”Arch Ophthalmol, V. 106, 1988, pp. 973-977.

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