Use of 5′-methylthioadenosine (MTA) in the prevention...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S027300

Reexamination Certificate

active

07820637

ABSTRACT:
5′-methylthioadenosine (MTA), its pharmaceutically acceptable salts and/or prodrugs may be used in the prevention and/or treatment of autoimmune diseases, such as, for example, Multiple Sclerosis (MS), as well as in the prevention and/or treatment of transplant rejection.

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Hevia et al., “5′-Methylthioadenosine Modulates the Inflammatory Response to Endotoxin in Mice and in Rat Hepatocytes,” Hepatology, vol. 39, No. 4., (2004), pp. 1088-1098.
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Davidson, Anne., M.B., B.S., et al., Autoimmune Diseases, New England Journal of Medicine, 2001, pp. 340-350, vol. 345, No. 5.
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Santana, Maria Angelica, et al., Cell Biology of T Cell Activation and Differentiation, International Review of Cytology, 2006, pp. 217-274, vol. 250.

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