Use of 5-phenyl-2-furan esters, amides and ketones as neuroprote

Details Use of 5-phenyl-2-furan esters, amides and ketones as neuroprote Use of 5-phenyl-2-furan esters, amides and ketones as neuroprote

1989-06-23

1992-06-02

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3134

Patent

active

051187086

ABSTRACT:
The present invention encompasses methods of using a 5-phenyl-2-furan esters, amides and ketones and compositions thereof to prevent or limit neuronal death or degeneration in a human or lower animal. These methods comprise systemically administering to such human or other animal a safe and effective amount of a compound of the formula: ##STR1## wherein (1) X is halo or nil; and Y is a substituent selected from the group consisting of unsubstituted or halogen-substituted methyl, halo, nitro, amino, and methoxy; and

REFERENCES:
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patent: 4128550 (1978-12-01), Pelosi, Jr. et al.
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patent: 4403097 (1983-09-01), Pelosi, Jr. et al.
Oleinik, A. F. et al., "Synthesis and Tuberculostatic Activity of 5-arylpyromucic acid derivatives", Pharmaceutical Chemical Journal, vol. 10, No. 4 (Apr. 1976), pp. 463-465.
Burch, H., R. White, G. Wright & M. Goldenberg, "phenyl furans IV: spasmolytic 3-diethylamino-2,2-(dimethyl)propyl Esters of 5-substituted phenyl-2-furancarboxylic acids", Journal of Pharmaceutical Sciences, vol. 69, No. 1 (Jan. 1980), pp. 107-110.
Goldenberg, M., "F-461, 3-diethylamino-2,2-dimethylpropyl 5-(P-nitrophenyl)-2-furoate hydrochloride, a new non-anticholinergic spasmolytic and a gastric acid inhibitor", Arch. Int. Pharmacodyn, vol. 222, pp. 27-39 (1976).

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