Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-08-30
1996-05-28
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514254, 514259, 514278, 514304, 514415, 514657, A61K 31495, A61K 3150, A61K 31505, A61K 3144, A61K 31405, A61K 31135
Patent
active
055211836
ABSTRACT:
The present invention is based on the finding that 5-HT receptor ligands are useful in treating experimental models of clinically encountered pruritus (itch). A 5-HT ligand as used in this specification is a compound capable of binding with some selectivity to one or more of the 5-HT receptor sites. Systemic administration of 5-HT agonists and antagonists causes a reduction in the number of itch-scratch responses to an ocular challenge by allergenic antigens. Therefore, the present invention relates to a method for treating pruritus by administering systemically a therapeutically effective amount of a 5-HT agonist or antagonist to a mammal afflicted with pruritus. The 5-HT ligands may, for example, be selected from the group consisting of 5-HT.sub.1, 5-HT.sub.2, 5-HT.sub.3, and 5-HT.sub.4 agonists, partial agonists and antagonists.
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Nieves Amelia L.
Woodward David F.
Allergan
Baran Robert J.
Cintins Marianne M.
Hoch James M.
Jarvis William R. A.
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