Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514299, 514311, 514312, 514313, 546 14, 546112, 546152, 546153, 546155, 546156, 546168, 546170, 546174, 546176, 546 15, A61K 3141, C07D22120, C07D21554, C07D21520

Patent

active

045769494

ABSTRACT:
The present invention also provides novel compositions of matter. In particular, the present invention provides novel 3-substituted compounds of formula I which are from among the selected 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines having use as inhibitors of the synthesis of leukotrienes and as inhibitors of the action of lipoxygenase in mammalian metabolism.

REFERENCES:
patent: 2868691 (1959-01-01), Porush et al.
patent: 4294759 (1981-10-01), Smith
Samuelsson, Trends in Pharmacological Sciences, 5:227 (1980).
Samuelsson, et al., Annu. Rev. Biochem., 47:997-1029 (1978).
Samuelsson et al., Prostaglandins, 19:645 (1980).
D. J. Brien, et al., J. Chem. Soc. Chem. Commun., 1982, 133.
J. Epsztajn et al., Rocz. Chem., 1970, 44, 431 (CA72:132478h).
E. Reimann et al., Arch, Pharm., 1979, 312, 940.
Y. I. Chumakov, CA 77, 5306.
J. Epstajn et al., Bull. Acad. Pol. Sci., Ser. Sci. Chem., 1975, 23 917 (CA 85:46792t).
J. Epsztajn et al., Rocz. Chem., 1969, 43, 807 (CA 71:112773b).
W. Dammertz, E. Reimann, Arch. Pharm., 1980, 313, 826.
E. Reimann et al., Arch. Pharm., 1981, 314, 302.
U. Basu Ann. Chem., 530, 131 (1937), see CA 31, 3919 (1939).
E. Schroder et al., Eur. J. Med. Chem. (1979), 14, 309.
U.S. patent application Ser. No. 561,601.
P. E. Eaton et al., Synthesis, 1983, p. 796.
C. Ainsworth, Org. Syn., 1963, 4, p. 536.
R. Lukes, et al., Coll. Czech. Chem. Comm., 1960, 25, p. 607.
Maitle et al., Synthesis, 1981, p. 130.
J. Epsztajin et al., Rocz. Chem., 1975, 49, p. 123.
Bach, M. K. et al., A. New Inhibitor of Leukotriene C and D Synthesis: In Vitro Studies, Prostaglandins 23, 759-771, 1982.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2306332

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.