Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a

Details Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a

1992-03-27

1997-02-18

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

056042450

ABSTRACT:
The present invention concerns the use of 4-amino-1-(2-pyridyl)piperidines of general formula (I') ##STR1## wherein R' represents hydrogen, a halogen atom, a methyl, methylthio, trifluoromethyl, trifluoromethylthio, (C.sub.1 -C.sub.3)alkoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, or phenoxy group optionally substituted with a halogen atom, a trifluoromethyl, (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, or cyano group, or of a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment or prophylaxis of those conditions deriving from disorders of the serotoninergic systems wherein a serotoninergic action selectively mediated by the 5-HT.sub.3 receptors is required, e.g. affective disorders, anxiety, psychotic troubles, constipation.

REFERENCES:
patent: 4409228 (1983-10-01), Nisato et al.
European Journal of Pharmacology; 237 (1993) 299-309; Bachy et al.; "SR 57227A: A Potent and Selective Agonist at Central and Peripheral 5-HT.sub.3 Receptors in vitro and in vivo".
European Journal of Pharmacology; 163 (1989) 397-398; Schmidt et al.; "Antidepressant Interactions with 5-Hydroxytryptamine.sub.3 Receptor Binding Sites".
R. W. Fuller et al., "Neurochemical effects of CM 57227 and CM 57373, two anorectic agents, on brain serotonin neurons in rats," Neurochem. Int., vol. 16, No. 3 (1990), pp. 309-312.
S. Garattini et al., "Reduction of food intake by manipulation of central serotonin. Current experimental results," Dialog Information Services, Inc., File 155, AN=07215162, citing, Br. J. Psych. Suppl., (Dec. 1989), pp. 41-51.
A. W. Schmidt et al., "Antidepressant interactions with 5-hydroxytryptamine.sup.3 receptor binding sites," Chemical Abstracts, vol. 111, No. 3, 17629k, citing, Eur. J. Pharmacol. (1989) pp. 397-398.

Affiliated with

Also associated with

Rating

Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1602774