Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S631000, C514S878000, C548S150000, C564S229000

Reexamination Certificate

active

07662840

ABSTRACT:
This invention relates to a pharmaceutical composition containing 4-[(4-thiazolyl)phenoxyl]alkoxy-benzamidine derivatives expressed by the following formula 1 for the prevention and treatment of osteoporosis and more particularly, to the use of 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine or N-hydroxy-4-{5-[4-(5-iso-propyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine expressed by the following formula 1, which is known as an antagonist of leukotriene-B4receptor, as a pharmaceutical composition for the prevention and treatment of osteoporosis. [Formula 1], wherein, R is a hydrogen atom or a hydroxy group.

REFERENCES:
patent: 5451700 (1995-09-01), Morrissey et al.
patent: 5521315 (1996-05-01), Underiner et al.
patent: 6150390 (2000-11-01), Suh et al.
patent: 2002241361 (2007-05-01), None
patent: 02707300.6 (2007-02-01), None
patent: 98-071076 (1998-10-01), None
patent: 10-0454767 (2004-10-01), None
Sung-Eun Lee, Design, Syntheses, and evaluation of the functional molecules for the treatment of the LTB4 related disease and electroluminescent device:, Doctoral Dissertation, Department of Chemistry, Graduate School of Arts and Science, Busan University, South Korea, Aug. 1999.
Tai, V. “The effects of Leukotriene B4 on osteoclast formatin and osteoclastic bone resorption and the role of osteoblastic cells in these processes”, 1997, National Library of Canada, pp. 1-105.
Traianedes, K.; Dallas, M.R.; Garrett, I.R.; Mundy, G.R.; Bonewald, L.F. “5-Lipoxygenase Metabolites Inhibit Bone Formation in Vitro”, 1998, Endocrinology, vol. 139(7), pp. 3178-3184.
Tong, W.Q.; Whitesell, G.; “In situ salt screening—a useful technique for discovery support and preformulation studies”, May 1998, Pharmaceutical development and technology, vol. 3(2), abstract. Paper is orderd.
Sung-Eun Lee, “Design, Syntheses, and evaluation of the functional molecules for the treatment of the LTB4related disease and electroluminescent device”, Doctoral Dissertation, Department of Chemistry, Graduate School of Arts and Science, Busan Univ., South Korea, Aug. 1999.
Ford-Hutchinson, A.W., et al., Nature (London), 286, 264-265, 1980.
Meghji, S., et. al., Calcif. Tiss. Int., 36, 139-149, 1988.
Mundy, G. R., et al., J. Bio. Chem., 268, 10087-10094, 1993.
Bonewald, L. F., et al., J. Bone Miner. Res., 11, 521-529, 1996.
Bonewald, L. F., et al., J. Bone Miner. Res., 11, 1619-1627, 1996.
Gregg Wesolowski, et al., Experimental Cell Research, 219, 679-686, 1995.
Eijiro Jimi, et al., Endocrinology, 137, p. 2187-2190, 1996.
Y. Wada, et al., Bone, 22, 479-485, 1998.
Sung-Eun Lee, “Design,Syntheses, and evaluation of the functional molecules for the treatment of the LTB4related disease and electroluminescent device”, Doctoral Dissertation, Department of Chemistry, Graduate School of Arts and Science, Busan Univ., South Korea, Aug. 1999.
Ford-Hutchinson, A. W., et al.,Nature(London), 286, 264-265, 1980.
Meghji, S., et. al.,Calcif. Tiss. Int., 36, 139-149, 1988.
Mundy, G. R., et al.,J. Bio. Chem., 268, 10087-10094, 1993.
Bonewald, L. F., et al.,J. Bone Miner. Res., 521-529, 1996.
Bonewald, L. F., et al.,J. Bone Miner. Res., 1619-1627, 1996.
Gregg Wesolowski, et al.,Experimental Cell Research, 219, 679-686, 1995.
Eijiro Jimi, et al.,Endocrinology, 137, p. 2187-2190, 1996.
Y. Wada, et al.,Bone, 22, 479-485, 1998.
Brooks, et al., “Modulators of Leukotriene Biosynthesis and Receptor Activation”, Journal of Medicinal Chemistry, vol. 39, No. 14, Jul. 5, 1998.

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